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Titolo:
Role of thromboxane A(2) and platelet activating factor in early haemodynamic response to lipopolysaccharide in rats
Autore:
Bochenski, J; Chlopicki, S; Gryglewski, RJ;
Indirizzi:
Jagiellonian Univ, Coll Med, Dept Pharmacol, PL-31531 Krakow, Poland Jagiellonian Univ Krakow Poland PL-31531 rmacol, PL-31531 Krakow, Poland
Titolo Testata:
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
fascicolo: 2, volume: 50, anno: 1999,
pagine: 287 - 297
SICI:
0867-5910(199906)50:2<287:ROTAAP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; FACTOR-RECEPTOR ANTAGONISM; INDUCED LUNG DYSFUNCTION; ENDOTOXIN-SHOCK; PULMONARY; INVOLVEMENT; HYPOTENSION; INHIBITOR; SHEEP; INDUCTION;
Keywords:
lipopolysaccharide; haemodynamic response; thromboxane; platelet-activating factor; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Chlopicki, S Jagiellonian Univ, Coll Med, Dept Pharmacol, Grzegorzecka 16,PL-31531 Krakow, Poland Jagiellonian Univ Grzegorzecka 16 Krakow Poland PL-31531 and
Citazione:
J. Bochenski et al., "Role of thromboxane A(2) and platelet activating factor in early haemodynamic response to lipopolysaccharide in rats", J PHYSL PH, 50(2), 1999, pp. 287-297

Abstract

The mechanism of early pulmonary and systemic haemodynamic response to intravenous infusion of LPS from Escherichia coli was investigated in anasthetised Wistar rats. 10 mg of LPS given at a rate of 4 mg/kg/min but not at a rate of 1 mg/kg/min induced an increase in pulmonary arterial pressure (SAP) and a fall in systemic arterial pressure (SAP). Pretreatment with a PAF receptor antagonist; WEB 2170 (5 and 25 mg/kg) inhibited both PAP and SAP responses to LPS (4 mg/kg/min) while an inhibitor of thromboxane synthesis; Camonagrel (10 and 20 mg/kg) abolished PAP response without a major effect on SAP response to LPS. In conclusion, both PAF and TXA(2) mediate LPS induced rise in pulmonary arterial pressure while LPS-induced fall in systemic arterial pressure is mediated by PAF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 03:15:50