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Titolo:
An early description of striatonigral degeneration
Autore:
Berciano, J; Combarros, O; Polo, JM; Pascual, J; Oterino, A;
Indirizzi:
Univ Hosp Marques Valdecilla, Serv Neurol, E-39008 Santander, Spain Univ Hosp Marques Valdecilla Santander Spain E-39008 08 Santander, Spain
Titolo Testata:
JOURNAL OF NEUROLOGY
fascicolo: 6, volume: 246, anno: 1999,
pagine: 462 - 466
SICI:
0340-5354(199906)246:6<462:AEDOSD>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
OLIVOPONTOCEREBELLAR ATROPHY;
Keywords:
olivopontocerebellar atrophy; striatonigral degeneration; Parkinson's disease; Huntington's disease; Pick's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Berciano, J Univ Hosp Marques Valdecilla, Serv Neurol, E-39008 Santander, Spain Univ Hosp Marques Valdecilla Santander Spain E-39008 , Spain
Citazione:
J. Berciano et al., "An early description of striatonigral degeneration", J NEUROL, 246(6), 1999, pp. 462-466

Abstract

Our aim was to revisit the papers published by Scherer 1933 describing four cases of sporadic olivopontocerebellar atrophy (OPCA) thought to represent the earliest description of striatonigral degeneration. One should note that extrapyramidal rigidity associated with OPCA was then considered a typeof cerebellar parkinsonism. Two of Scherer's four patients had severe parkinsonism masking cerebellar signs. Pathologically both cases displayed marked degeneration of the striatum and nigra and partially developed pontocerebellar atrophy. Cerebellar ataxia was the outstanding feature in the other two, their pathological study showing severe pontocerebellar lesions and incipient striatonigral atrophy. Scherer stated that the severity of parkinsonism in OPCA is not correlated with the degree of cerebellar degeneration but with that of striatum and nigra. We conclude that Scherer gave the firstaccurate description of striatonigral degeneration. Moreover, his contribution was essential in ruling out die prevalent notion of cerebellar parkinsonism in OPCA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:12:34