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Titolo:
Interaction between lifetime captopril treatment and NaCl-sensitive hypertension in spontaneously hypertensive rats and Wistar-Kyoto rats
Autore:
Fang, ZW; Sripairojthikoon, W; Calhoun, DA; Zhu, ST; Berecek, KH; Wyss, JM;
Indirizzi:
Univ Alabama, Dept Cell Biol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 Cell Biol, Birmingham, AL 35294 USA Univ Alabama, Dept Physiol & Biophys, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 & Biophys, Birmingham, AL 35294 USA Univ Alabama, Dept Med, Vasc Biol & Hypertens Program, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 ns Program, Birmingham, AL 35294 USA Mahidol Univ, Fac Dent, Dept Anat, Bangkok 10700, Thailand Mahidol Univ Bangkok Thailand 10700 , Dept Anat, Bangkok 10700, Thailand
Titolo Testata:
JOURNAL OF HYPERTENSION
fascicolo: 7, volume: 17, anno: 1999,
pagine: 983 - 991
SICI:
0263-6352(199907)17:7<983:IBLCTA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME-INHIBITION; CIRCADIAN BLOOD-PRESSURE; ANGIOTENSIN-II RECEPTORS; LONG-TERM; PLASMA-RENIN; HEART-RATE; BRAIN; SALT; NOREPINEPHRINE; PREVENTION;
Keywords:
dangiotensin converting enzyme; circadian rhythm; neuronal regulation of arterial pressure; salt-sensitivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Wyss, JM Univ Alabama, Dept Cell Biol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 l, Birmingham, AL 35294 USA
Citazione:
Z.W. Fang et al., "Interaction between lifetime captopril treatment and NaCl-sensitive hypertension in spontaneously hypertensive rats and Wistar-Kyoto rats", J HYPERTENS, 17(7), 1999, pp. 983-991

Abstract

Design Previous studies that were based on daytime arterial pressure recordings indicate that lifetime treatment with captopril exacerbates the hypertensive response to a high NaCl diet in spontaneously hypertensive rats (SHR) but has no such effect in normotensive Wistar-Kyoto (WKY) rats. The present study used 24-h recording methods to examine the hypothesis that duringthe normal waking hours of rats (night-time) the hypertensive response to a high NaCl diet is exacerbated in SHR and induced in WKY rats treated withlifetime captopril,Methods SHR and WKY rats were (1)untreated, (2), lifetime captopril treated or (3) lifetime captopril treated but removed from the treatment 2 weeks prior to exposure to a high (8%) NaCl diet. Results Compared to untreated SHR, in SHR that were continuously treated with captopril, the high NaCl diet caused a more rapid and greater rise in arterial pressure. Discontinuation of the captopril treatment did not significantly diminish this NaCl-sensitivity. In untreated WKY rats, the high NaCl diet did not alter mean arterial pressure, but in the lifetime captopril-treated WKY rats the high NaCl diet induced a rapid rise in arterial pressure. In WKY rats, discontinuation of the lifetime captopril treatment did not diminish this NaCl-induced rise in arterial pressure, even though baseline mean arterial pressure in this group is similar to that in untreated WKY rats. Conclusions Lifetime captopril treatment accelerates the hypertensive response to a high NaCl diet in SHR, and it induces a similar response in WKY rats, In both strains, the lifetime captopril treatment causes a change in the response that is not dependent on concurrent administration of the drug. This finding further suggests that lifetime captopril treatment causes a long-term resetting of cardiovascular response mechanisms. J Hypertens 1999,17:983-991 (C) Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/11/20 alle ore 02:37:21