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Titolo:
Inhibiting scrapie neuroinvasion by polyene antibiotic treatment of SCID mice
Autore:
Beringue, V; Lasmezas, CI; Adjou, KT; Demaimay, R; Lamoury, F; Deslys, JP; Seman, M; Dormont, D;
Indirizzi:
CEA, Serv Neurovirol, DSV DRM, CRSSA, F-92265 Fontenay Aux Roses, France CEA Fontenay Aux Roses France F-92265 F-92265 Fontenay Aux Roses, France Univ Paris 07, Inst Jacques Monod, Lab Immunodifferenciat, F-75251 Paris, France Univ Paris 07 Paris France F-75251 nodifferenciat, F-75251 Paris, France Labs Mayoly Spindler, Chatou, France Labs Mayoly Spindler Chatou FranceLabs Mayoly Spindler, Chatou, France
Titolo Testata:
JOURNAL OF GENERAL VIROLOGY
, volume: 80, anno: 1999,
parte:, 7
pagine: 1873 - 1877
SICI:
0022-1317(199907)80:<1873:ISNBPA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
INCUBATION PERIOD; AGENT REPLICATION; AMPHOTERICIN-B; IMMUNE-SYSTEM; PRION PROTEIN; MOUSE SPLEEN; PATHOGENESIS; CELLS; INFECTION; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Dormont, D CEA, Serv Neurovirol, DSV DRM, CRSSA, 60-68 Av Div Leclerc,BP 6, F-92265 Fontenay Aux Roses, France CEA 60-68 Av Div Leclerc,BP 6 FontenayAux Roses France F-92265
Citazione:
V. Beringue et al., "Inhibiting scrapie neuroinvasion by polyene antibiotic treatment of SCID mice", J GEN VIROL, 80, 1999, pp. 1873-1877

Abstract

The polyene antibiotic MS-8209 is currently one of the most effective drugs in the treatment of experimental scrapie, However, its mechanism of action;and its site of intervention in the pathogenetical process of scrapie infection are largely unknown. It has been shown previously that the infectionof immunodeficient SCID mice by the peripheral route provides a reliable model for direct scrapie neuroinvasion, bypassing the lymphoreticular system. Indeed, a proportion of SCID mice develop scrapie after a similar time toimmunocompetent mice, despite their severe immune impairment. This model is now used to clarify the targets of MS-8209, In SCID mice, MS-8209 treatment protected against infection but did not prolong survival time. In SCID mice immunologically reconstituted prior to inoculation, the drug delayed the disease without an effect on the attack rate. These findings strongly suggest that MS-8209 acts by hampering the first step of the neuroinvasion process, i.e. the uptake of the infectious agent by peripheral nerve endings. The mechanism leading to the inhibition of agent propagation to nervous cells is discussed with regard to the properties of polyene antibiotics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 08:51:06