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Titolo:
Studies on the anti-allergic activity of Mikania glomerata
Autore:
Fierro, IM; da Silva, ACB; Lopes, CD; de Moura, RS; Barja-Fidalgo, C;
Indirizzi:
Univ Fed Rio de Janeiro, Inst Biol, Dept Farmacol & Psicobiol, BR-20551030Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Rio De Janeiro Brazil BR-20551030 BCeiro, Brazil
Titolo Testata:
JOURNAL OF ETHNOPHARMACOLOGY
fascicolo: 1, volume: 66, anno: 1999,
pagine: 19 - 24
SICI:
0378-8741(199907)66:1<19:SOTAAO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHARMACOLOGICAL MODULATION; PLEURISY; RATS;
Keywords:
Mikania glomerata; pleurisy; anti-allergic activity; anti-inflammatory activity; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Fierro, IM Univ Fed Rio de Janeiro, Inst Biol, Dept Farmacol & Psicobiol, Ave 28 Setembro 87 Fds 5o Andar, BR-20551030 Rio De Janeiro, Brazil Univ Fed Rio de Janeiro Ave 28 Setembro 87 Fds 5o Andar Rio De Janeiro Brazil BR-20551030 BC
Citazione:
I.M. Fierro et al., "Studies on the anti-allergic activity of Mikania glomerata", J ETHNOPHAR, 66(1), 1999, pp. 19-24

Abstract

A fraction (MG1) obtained from the ethanolic extract of Mikania glomerata Sprengel (Compositae), popularly known as 'guaco' and used as 'an' anti-allergic and anti-inflammatory agent, was evaluated for these properties on ovalbumin-induced allergic pleurisy and in models of local inflammation induced by biogenic amines, carrageenan and PAF. Plasma exudation as well as neutrophil and eosinophil infiltration evoked by the intrapleural injection ofthe antigen were significantly reduced by the fraction. Likewise, PAF-induced pleural neutrophil migration was inhibited by the treatment with MG1. On the other hand, pre-treatment of the animals with MG1 failed to modify the pleurisy induced by histamine, serotonin or carrageenan. These results suggest that MG1 is effective in inhibiting immunologic inflammation but did not affect acute inflammatory response caused by other agents. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:15:31