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Titolo:
Multiple source analysis of interictal spikes: Goals, requirements, and clinical value
Autore:
Scherg, M; Bast, T; Berg, P;
Indirizzi:
Univ Heidelberg Hosp, Dept Neurol, Sect Biomagnetism, D-69120 Heidelberg, Germany Univ Heidelberg Hosp Heidelberg Germany D-69120 9120 Heidelberg, Germany Univ Heidelberg Hosp, Dept Pediat Neurol, Sect Biomagnetism, D-69120 Heidelberg, Germany Univ Heidelberg Hosp Heidelberg Germany D-69120 9120 Heidelberg, Germany Univ Konstanz, Dept Psychol, D-7750 Constance, Germany Univ Konstanz Constance Germany D-7750 sychol, D-7750 Constance, Germany
Titolo Testata:
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
fascicolo: 3, volume: 16, anno: 1999,
pagine: 214 - 224
SICI:
0736-0258(199905)16:3<214:MSAOIS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; LOCALIZATION; PROPAGATION;
Keywords:
focal epilepsy; EEG; interictal spike; multiple source analysis; source model; dipole localization; neuroimaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Scherg, M Univ Heidelberg Hosp, Dept Neurol, Sect Biomagnetism, Neuenheimer Feld 400, D-69120 Heidelberg, Germany Univ Heidelberg Hosp Neuenheimer Feld 400 Heidelberg Germany D-69120
Citazione:
M. Scherg et al., "Multiple source analysis of interictal spikes: Goals, requirements, and clinical value", J CL NEURPH, 16(3), 1999, pp. 214-224

Abstract

When evaluating interictal spikes using dipole source analysis it is important to account for multiple sources and the overlapping background EEG. Analyses of spike peaks may be modeling only propagated sources. Careful filtering of averaged spike data and multiple source analysis can provide useful information about the onset of epileptiform activity. A forward high-passfilter can help to enhance the initial spike activity during onset over the propagated activity. These points are illustrated with examples of a temporal, a parietal, and a frontal averaged spike. Multiple source analysis was applied using a genetic algorithm and a sequential strategy, in one case including a model of background alpha activity. Multiple source analysis could model sources describing the onset activity that were distinct in location and orientation from the propagated activity. In all cases, the prominent peak on the scalp was dominated by the contribution of propagated sources. Clinical interpretation benefits from an approach that combines the temporal evolution of EEG scalp topography and multiple source activities with the information from localization and orientation of equivalent dipole sources to identify the cortical generators underlying the earliest phase of interictal spikes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:35:47