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Titolo:
Chemoprotective effects of neem leaf extract on 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis
Autore:
Balasenthil, S; Arivazhagan, S; Nagini, S;
Indirizzi:
Annamalai Univ, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 , Tamil Nadu, India
Titolo Testata:
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
fascicolo: 1, volume: 26, anno: 1999,
pagine: 9 - 15
SICI:
0912-0009(1999)26:1<9:CEONLE>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
1-OXIDE-INDUCED ORAL CARCINOGENESIS; GLUTATHIONE S-TRANSFERASES; PLANT-PRODUCTS; REDUCED GLUTATHIONE; LIPID-PEROXIDATION; CHEMOPREVENTION; QUERCETIN; CANCER; RATS; INHIBITION;
Keywords:
oral cancer; DMBA; chemoprevention; neem; lipid peroxidation; antioxidants; detoxifying enzymes; glutathione;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Nagini, S Annamalai Univ, Dept Biochem, Annamalainagar 608002, Tamil Nadu,India Annamalai Univ Annamalainagar Tamil Nadu India 608002 du, India
Citazione:
S. Balasenthil et al., "Chemoprotective effects of neem leaf extract on 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinogenesis", J CL BIOC N, 26(1), 1999, pp. 9-15

Abstract

The chemoprotective effects of neem (Azadirachta indica A. Juss.) on hepatic and circulatory lipid peroxidation and on antioxidant and detoxifying enzyme status during 7,12-dimethylbenz[a]anthracene (DMBA)-induced buccal pouch carcinogenesis was investigated in Syrian male hamsters. Enhanced lipid peroxidation in the liver and circulation of tumor-bearing animals was accompanied by a significant decrease in reduced glutathione (GSH) concentration and activities of the detoxifying enzymes glutathione peroxidase (GPx) and glutathione-S-transferase (GST). Administration of neem leaf extract significantly decreased the formation of lipid peroxides and enhanced the levels of antioxidants and detoxifying enzymes. We speculate that neem leaf extract exerts its effects by modulating lipid peroxidation and enhancing antioxidant and detoxification systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 22:50:36