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Titolo:
Fluconazole, with or without dexamethasone for experimental cryptococcosis: impact of treatment timing
Autore:
Lortholary, O; Nicolas, M; Soreda, S; Improvisi, L; Ronin, O; Petitjean, O; Dupont, B; Tod, M; Dromer, F;
Indirizzi:
Inst Pasteur, Unite Mycol, F-75724 Paris 15, France Inst Pasteur Paris France 15 teur, Unite Mycol, F-75724 Paris 15, France Univ Paris 13, Hop Avicenne, CREPIT 93, Serv Pharmacotoxicol, F-93009 Bobigny, France Univ Paris 13 Bobigny France F-93009 acotoxicol, F-93009 Bobigny, France
Titolo Testata:
Journal of antimicrobial chemotherapy
fascicolo: 6, volume: 43, anno: 1999,
pagine: 817 - 824
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL PNEUMOCOCCAL MENINGITIS; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; AMPHOTERICIN-B; CEREBROSPINAL-FLUID; MURINE MODEL; SYSTEMIC MYCOSES; PHARMACOKINETICS; COMBINATION; EFFICACY; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Dromer, F Inst Pasteur, Unite Mycol, 25 Rue Dr Roux, F-75724 Paris 15, France Inst Pasteur 25 Rue Dr Roux Paris France 15 24 Paris 15, France
Citazione:
O. Lortholary et al., "Fluconazole, with or without dexamethasone for experimental cryptococcosis: impact of treatment timing", J ANTIMICRO, 43(6), 1999, pp. 817-824

Abstract

The time of initiation of fluconazole treatment with or without dexamethasone, and the impact on mycological outcome and drug pharmacokinetics were assessed in a murine model of disseminated cryptococcosis. Non-infected miceand mice with disseminated cryptococcosis were given saline, dexamethasone, or fluconazole +/- dexamethasone, 1 or 8 days after infection. Cfus were counted in tissues, and fluconazole concentrations were determined in plasma and tissues by HPLC and a bioassay. Despite fluconazole tissue and plasmaconcentrations which were above the minimal inhibitory concentration, the numbers of cfus in brain and lung tissues were reduced after early (P = 0.002 and 0.04, respectively), but not after late fluconazole treatment. The administration of dexamethasone did not have a deleterious effect on the number of cfus, fluconazole pharmacokinetics or antifungal activity. In conclusion, the size of the fungal burden influences the effective level of fluconazole activity in lung and brain. These results strongly suggest that potential antifungal agents should be studied following both early and late administration in experimental cryptococcosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:10:07