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Titolo:
Efficacy of trovafloxacin in an in vitro pharmacodynamic simulation of an intraabdominal infection
Autore:
Alou, L; Anta, ML; Del Potro, MG; Fuentes, F; Balcabao, IP; Gomez-Lus, ML; Prieto, J;
Indirizzi:
Univ Complutense Madrid, Sch Med, Dept Microbiol, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 biol, E-28040 Madrid, Spain
Titolo Testata:
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
fascicolo: 2, volume: 12, anno: 1999,
pagine: 135 - 139
SICI:
0924-8579(199907)12:2<135:EOTIAI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BACTERICIDAL ACTIVITY; CIPROFLOXACIN; SPARFLOXACIN; CEFOTAXIME;
Keywords:
trovafloxacin; intraabdominal infection; pharmacodynamic simulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Prieto, J Univ Complutense Madrid, Sch Med, Dept Microbiol, Av ComplutenseS-N, E-28040 Madrid, Spain Univ Complutense Madrid Av Complutense S-N Madrid Spain E-28040
Citazione:
L. Alou et al., "Efficacy of trovafloxacin in an in vitro pharmacodynamic simulation of an intraabdominal infection", INT J ANT A, 12(2), 1999, pp. 135-139

Abstract

An in vitro model simulating trovafloxacin concentrations in human serum after standard doses was used to investigate the activity of this drug with time against Bacteroides fragilis, Escherichia coil, Enterococcus faecalis and Staphylococcus aureus. Antibiotic concentrations used for each incubation period were: 4.24 mg/l (0-1 h), 3.69 mg/l (1-3 h), 3.25 mg/l (3-6 h), 2.38 mg/l (6-8 h), 1.35 mg/l (8-24 h). A 99.9% initial inoculum reduction (>3log(10) cfu/ml) was defined as bactericidal activity. Bactericidal activity against these organisms was obtained with trovafloxacin after the first hour of incubation, and similar activity was obtained against B. fragilis, E. faecalis and S. aureus after 3 h, when they were tested individually. When the strains were tested as mixed culture, there was bactericidal activityagainst E. coli after 1 h incubation and after 3 h for S. aureus. This activity was observed against B. fragilis and E. faecalis after 6 h incubationin the mixed culture assays and after 3 h when organisms were tested individually. Regrowth was not observed over a 24 h period. These data show thattrovafloxacin might be effective in intraabdominal infections caused by mixed aerobic and anaerobic microorganisms. (C) 1999 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:28:05