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Titolo:
Neurotransmitter transporters: Target for endocrine regulation
Autore:
Figlewicz, DP; Patterson, TA; Zavosh, A; Brot, MD; Roitman, M; Szot, P;
Indirizzi:
VA Puget Sound Hlth Care Syst, Dept Metab Endocrinol 151, Seattle, WA 98108 USA VA Puget Sound Hlth Care Syst Seattle WA USA 98108 Seattle, WA 98108 USA Univ Washington, Dept Psychol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Psychol, Seattle, WA 98195 USA Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 t & Behav Sci, Seattle, WA 98195 USA VA Puget Sound Hlth Care Syst, Ctr Geriatr Res Educ & Clin, Seattle, WA 98108 USA VA Puget Sound Hlth Care Syst Seattle WA USA 98108 Seattle, WA 98108 USA
Titolo Testata:
HORMONE AND METABOLIC RESEARCH
fascicolo: 5, volume: 31, anno: 1999,
pagine: 335 - 339
SICI:
0018-5043(199905)31:5<335:NTTFER>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT DOPAMINE TRANSPORTER; BRAIN GABA TRANSPORTER; MESSENGER-RNA; SEROTONIN TRANSPORTERS; NOREPINEPHRINE UPTAKE; FUNCTIONAL REGULATION; EXPRESSION CLONING; NEURONAL CULTURES; LOCUS-CERULEUS; COCAINE;
Keywords:
insulin; glucocorticoids; aldosterone; transporters; dopamine; estrogen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Figlewicz, DP VA Puget Sound Hlth Care Syst, Dept Metab Endocrinol 151, 1660 So Comumbian Way, Seattle, WA 98108 USA VA Puget Sound Hlth Care Syst 1660 So Comumbian Way Seattle WA USA 98108
Citazione:
D.P. Figlewicz et al., "Neurotransmitter transporters: Target for endocrine regulation", HORMONE MET, 31(5), 1999, pp. 335-339

Abstract

Aminergic signaling in the CNS is terminated by clearance from the synapsevia high-affinity transporter molecules in the presynaptic membrane. Relatively recent sequence identification of these molecules has now permitted the initiation of studies of regulation of transporter function at the cellular and systems levels. In vitro studies provide evidence that the transporters for dopamine, serotonin, and gamma-aminobutyric acid are substrates for regulation by protein kinase C signaling. In vivo studies provide evidence that insulin and adrenal and gonadal steroid hormones may regulate the synthesis and activity of the transporters. Future directions should permit evaluation of the role of endocrine regulation in neurotransmitter clearance, and thus in the maintenance of normal CNS aminergic signaling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:51:19