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Titolo:
Galanin and NPY, two peptides with multiple putative roles in the nervous system
Autore:
Hokfelt, T; Broberger, C; Diez, M; Xu, ZQ; Shi, T; Kopp, J; Zhang, X; Holmberg, K; Landry, M; Koistinaho, J;
Indirizzi:
Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden Karolinska InstStockholm Sweden S-17177 osci, S-17177 Stockholm, Sweden Dept Neurobiol, Xian, Peoples R China Dept Neurobiol Xian Peoples R China pt Neurobiol, Xian, Peoples R China Univ Kuopio, AI Virtanen Inst, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 nen Inst, FIN-70211 Kuopio, Finland
Titolo Testata:
HORMONE AND METABOLIC RESEARCH
fascicolo: 5, volume: 31, anno: 1999,
pagine: 330 - 334
SICI:
0018-5043(199905)31:5<330:GANTPW>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKEMIA INHIBITORY FACTOR; DORSAL-ROOT GANGLIA; VASOACTIVE INTESTINAL POLYPEPTIDE; NEURONAL DIFFERENTIATION FACTOR; HYPOTHALAMIC ARCUATE NUCLEUS; NEUROPEPTIDE-Y; MESSENGER-RNA; SYMPATHETIC NEURONS; SENSORY NEURONS; LOCUS-COERULEUS;
Keywords:
co-existence; depression; DRG neurons; feeding; neuropeptides; pain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Hokfelt, T Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 77 Stockholm, Sweden
Citazione:
T. Hokfelt et al., "Galanin and NPY, two peptides with multiple putative roles in the nervous system", HORMONE MET, 31(5), 1999, pp. 330-334

Abstract

The present brief overview we summarize results from several studies focusing on two neuropeptides, galanin and neuropeptide Y (NPY) in discrete neuronal systems, where they coexist with classic transmitters. On the basis ofstudies in different animal models we propose that these peptides may be involved in regulation of certain CNS functions and that drugs acting on their receptors may be of use in new therapeutic strategies. At the spinel level galanin and NPY are regulated in DRG neurons by nerve injury and in dorsal horn neurons by inflammation. It is possible that this leads to attenuation of pain sensitivity. Moreover, both peptides may exert trophic effects,for example to enhance regeneration. In the hypothalamic arcuate nucleus NPY and its receptors are part of the feeding circuitry, and we suggest thatderangement of these NPY neurons may at least in part underlay the lethal phenotype of anorectic mice, which die 22 days postnatally after showing decreased food intake and growth retardation. Expression of NPY and NPY receptors is changed in the hippocampus of mice comparatively early after prion inoculation, indicating that this peptide system is affected in this spongiform degenerative disease in a region of importance for learning and memory. Finally, galanin is co-localized with classic monoamine transmitters in two central systems, the dorsal raphe serotonin neurons and the locus coeruleus noradrenergic neurons. In both cases galanin causes hyperpolarization (at high concentrations) and prolongs monoamine-induced outward currents (atlow concentrations), thus modulating activity in two systems of importancefor many brain functions including mood regulation. It may therefore be interesting to analyse to what extent drugs affecting galaninergic transmission also may be efficient in the treatment of, for example, depression.

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Documento generato il 27/11/20 alle ore 07:08:02