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Titolo:
Measuring the cochlear blood flow and distortion-product otoacoustic emissions during reversible cochlear ischemia: a rabbit model
Autore:
Mom, T; Telischi, FF; Martin, GK; Lonsbury-Martin, BL;
Indirizzi:
Univ Dauvergne, Fac Med, Serv Otorhinolaryngol, F-63001 Clermont Ferrand, France Univ Dauvergne Clermont Ferrand France F-63001 Clermont Ferrand, France Univ Miami, Sch Med, Dept Otolaryngol, Miami, FL USA Univ Miami Miami FL USA Miami, Sch Med, Dept Otolaryngol, Miami, FL USA Univ Dauvergne, Fac Med, Lab Biophys Sensorielle 2R3, F-63001 Clermont Ferrand, France Univ Dauvergne Clermont Ferrand France F-63001 Clermont Ferrand, France
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 133, anno: 1999,
pagine: 40 - 52
SICI:
0378-5955(199907)133:1-2<40:MTCBFA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
PURE-TONE EXPOSURES; LASER-DOPPLER MEASUREMENTS; ACOUSTIC NEUROMA SURGERY; GUINEA-PIG COCHLEA; GERBIL COCHLEA; OCCLUSION;
Keywords:
cochlear blood flow; laser-Doppler flowmetry; reversible cochlear ischemia; distortion product otoacoustic emission; rabbit;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Mom, T Univ Dauvergne, Fac Med, Serv Otorhinolaryngol, BP 38, F-63001 Clermont Ferrand, France Univ Dauvergne BP 38 Clermont Ferrand France F-63001 rrand, France
Citazione:
T. Mom et al., "Measuring the cochlear blood flow and distortion-product otoacoustic emissions during reversible cochlear ischemia: a rabbit model", HEARING RES, 133(1-2), 1999, pp. 40-52

Abstract

Impairment to the cochlear blood flow likely induces many types of sensorineural hearing loss. Models using several small laboratory animals have been described in the literature that permit the simultaneous monitoring of the cochlear blood flow with laser-Doppler flowmetry and cochlear function using evoked responses. However, these models have not permitted a direct application of the resulting knowledge to the human condition, primarily due to differences in the translucence of the otic capsule between species. In the present study, to approximate conditions relevant to the human patient, the rabbit was utilized to develop a procedure in which laser-Doppler flowmetry could be used to measure the cochlear blood flow ill an animal with anopaque otic capsule. At the same time, the cochlear function was monitorednon-invasively using. distortion-product otoacoustic emissions. In this manner. a laser-Doppler probe was positioned in the round window niche and the cochlear function measured using distortion-product otoacoustic emissionsduring a systematic series of ischemic episodes. Cochlear ischemia was produced by deliberately compressing the eighth nerve complex at the porus of the internal acoustic meatus, for periods lasting from 1-3 min, while cochlear blood flow and distortion-product otoacoustic emission measures were obtained simultaneously before, during and following the occlusion. Results demonstrated that the cochlear blood flow sharply decreased within 1 s aftercompression onset, whereas distortion-product otoacoustic emissions showedobstruction-induced changes after a delay of several seconds, provided that the blood flow decreased, at least, 40%. Similarly, upon release of the compression, the cochlear blood now began to recover within 1 s, whereas therecovery of the corresponding distortion-product otoacoustic emissions wasslightly delayed. Although not apparent in the distortion-product otoacoustic emission recovery time course, the cochlear blood flow consistently overshot its initial baseline value during the recovery process. Thus, although cochlear ischemia produced changes in the distortion-product otoacoustic emission activity that generally followed the resulting alterations in the cochlear blood flow, the detailed relationship between the two measures wascomplex. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 09:15:33