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Titolo:
Regular fluctuations in growth hormone (GH) release determine normal humangrowth
Autore:
Gill, MS; Thalange, NKS; Foster, PJ; Tillmann, V; Price, DA; Diggle, PJ; Clayton, PE;
Indirizzi:
Univ Manchester, Dept Med, Endocrine Sci Res Grp, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England Univ Manchester, Royal Manchester Childrens Hosp, Dept Child Hlth, Manchester M27 4HA, Lancs, England Univ Manchester Manchester Lancs England M27 4HA M27 4HA, Lancs, England Univ Manchester, Dept Math, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England Univ Lancaster, Dept Math & Stat, Med Stat Unit, Lancaster LA1 4YF, England Univ Lancaster Lancaster England LA1 4YF nit, Lancaster LA1 4YF, England
Titolo Testata:
GROWTH HORMONE & IGF RESEARCH
fascicolo: 2, volume: 9, anno: 1999,
pagine: 114 - 122
SICI:
1096-6374(199904)9:2<114:RFIGH(>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SHORT-TERM GROWTH; LOWER LEG LENGTH; PREPUBERTAL CHILDREN; HEALTHY-CHILDREN; SHORT STATURE; FINAL HEIGHT; SECRETION; EXCRETION; PROFILES; PUBERTY;
Keywords:
body height; growth physiology; somatotropin urine; rhythmicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Clayton, PE Univ Manchester, Dept Med, Endocrine Sci Res Grp, Stopford Bldg,Oxford Rd,Manchester M13 9PT, Lancs, England Univ Manchester Stopford Bldg,Oxford Rd Manchester Lancs England M13 9PT
Citazione:
M.S. Gill et al., "Regular fluctuations in growth hormone (GH) release determine normal humangrowth", GROWTH H I, 9(2), 1999, pp. 114-122

Abstract

Growth hormone (GH) is the principal hormone associated with growth through childhood, but in a normal child the amount of GH secretion does not appear to be critical in the generation of normal growth rates. We have assessed the relationship between growth and urinary GH (uGH) output in a longitudinal study of 29 healthy prepubertal schoolchildren (13 male, 16 female; age 5.7-7.8 years) over 1 year. Height and UGH were measured three times a week. Individual height velocity curves were derived using non-linear regression, Growth was expressed in terms of the total increment over the year (Delta Ht, cm), height velocity standard deviation score (HVSDS) and the average size of individual growth spurts, Urinary GH data (ng) were expressed asa weekly average. Mean uGH did not correlate with stature or growth over the year. However, the coefficient of variation of uGH was correlated with height standard deviation score (HtSDS, r= 0.38, P < 0.05), while the relative constancy of short-term change in uGH (coefficient of incremental change, Delta(INC)) was inversely correlated with Delta Ht (r = - 0.44) and HVSDS (r= - 0.42, both P < 0.05) but not with HtSDS, Delta(INC) was also inversely correlated withthe average size of individual growth spurts derived from the height velocity curves (r= - 0.45, P < 0.05), Using time series analysis to identify rhythms in uGH excretion, a positive correlation was found between the magnitude of rhythms of a period of 2 to 4 weeks and HtSDS (r= 0.40, P < 0.05). These data demonstrate that variability in GH is a more important determinant of normal childhood growth rate than the amount of GH alone, Stature is correlated to the overall variability in GH release, while increment in height and the magnitude of individual growth spurts are influenced by the constancy of the GH profile. This would imply that once the GH dose has been replaced in GH deficiency, optimal growth could only be achieved by varying the pattern of GH administration. (C) 1999 Churchill Livingstone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 18:42:10