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Titolo:
Women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B before a rise in day 3 follicle-stimulating hormone
Autore:
Seifer, DB; Scott, RT; Bergh, PA; Arbogast, LK; Friedman, CI; Mack, CK; Danforth, DR;
Indirizzi:
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Univ Ctr Reprod Endocrinol & Fertil, Dept Obstet Gynecol & Reprod Sci, New Brunswick, NJ 08902 USA Univ Med & Dent New Jersey New Brunswick NJ USA 08902 swick, NJ 08902 USA St Barnabas Med Ctr, Inst Reprod Med & Sci, Livingston, NJ USA St BarnabasMed Ctr Livingston NJ USA prod Med & Sci, Livingston, NJ USA Ohio State Univ, Coll Med, Dept Obstet & Gynecol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 t & Gynecol, Columbus, OH 43210 USA
Titolo Testata:
FERTILITY AND STERILITY
fascicolo: 1, volume: 72, anno: 1999,
pagine: 63 - 65
SICI:
0015-0282(199907)72:1<63:WWDORM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUTEINIZED GRANULOSA-CELLS; DIMERIC INHIBIN; SECRETION;
Keywords:
inhibin B; FSH; ovarian reserve;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Seifer, DB Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Univ Ctr Reprod Endocrinol & Fertil, Dept Obstet Gynecol & Reprod Sci, 303 GeorgeSt,Suite 250, New Brunswick, NJ 08902 USA Univ Med & Dent New Jersey 303 George St,Suite 250 New Brunswick NJ USA 08902
Citazione:
D.B. Seifer et al., "Women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B before a rise in day 3 follicle-stimulating hormone", FERT STERIL, 72(1), 1999, pp. 63-65

Abstract

Objective: To test the hypothesis that women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B levels before a rise in day 3 serum FSH levels. Design: Case-control study. Setting: Tertiary care fertility center. Patient(s): One hundred nine women with nonovarian infertility (tubal factor or male factor) and 37 women with declining ovarian reserve who underwent assisted reproductive techniques. Intervention(s): None. Main Outcome Measure(s): Serum inhibin B and FSH levels, number of ampulesof gonadotropins administered, E-2 levels on the day of hCG administration, number of oocytes retrieved, clinical pregnancy rate, and cycle cancellation rate. Result(s): Women who had declining ovarian reserve as demonstrated by an increased gonadotropin requirement, a decreased E-2 response, fewer retrieved oocytes, a lower clinical pregnancy rate, and a higher cycle cancellationrate had lower day 3 serum inhibin B levels despite having nonelevated day3 FSK levels similar to those of women with nonovarian infertility. Conclusion(s): Women with declining ovarian responsiveness and clinical outcomes consistent with declining ovarian reserve had decreased day 3 serum inhibin B levels despite having nonelevated day 3 serum FSH concentrations. Declining ovarian reserve may be demonstrated by a decrease in day 3 inhibin B levels before a rise in day 3 FSH levels. (Fertil Steril(R) 1999;72:63-5. (C)1999 by American Society for Reproductive Medicine.).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 12:06:20