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Titolo:
Block by 5-hydroxytryptamine and apomorphine of recombinant human neuronalnicotinic receptors
Autore:
Nakazawa, K; Ohno, Y;
Indirizzi:
Natl Inst Hlth Sci, Div Pharmacol, Setagaya Ku, Tokyo 1588501, Japan Natl Inst Hlth Sci Tokyo Japan 1588501 Setagaya Ku, Tokyo 1588501, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 374, anno: 1999,
pagine: 293 - 299
SICI:
0014-2999(19990618)374:2<293:BB5AAO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE NEURONS; ACETYLCHOLINE-RECEPTORS; XENOPUS OOCYTES; CHROMAFFIN CELLS; GANGLION-CELLS; CHANNELS; DECREASES; SECRETION; RESPONSES; DOPAMINE;
Keywords:
human nicotinic receptor; 5-hydroxytryptamine; apomorphine; allosteric modulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Nakazawa, K Natl Inst Hlth Sci, Div Pharmacol, Setagaya Ku, 1-18-1 Kamiyoga, Tokyo 1588501, Japan Natl Inst Hlth Sci 1-18-1 Kamiyoga Tokyo Japan 1588501 Japan
Citazione:
K. Nakazawa e Y. Ohno, "Block by 5-hydroxytryptamine and apomorphine of recombinant human neuronalnicotinic receptors", EUR J PHARM, 374(2), 1999, pp. 293-299

Abstract

The effects of 5-hydroxytryptamine and apomorphine on human neuronal nicotinic acetylcholine receptor/channels were examined by expressing these channels in Xenopus oocytes. Functional channels were expressed by combining one type of a subunits (alpha 3 or alpha 4) and one type of beta subunits (beta 2 or beta 4). 5-Hydroxytryptamine (100 mu M to 1 mM) and apomorphine (10to 100 mu M) inhibited an inward current activated by acetylcholine in theoocytes expressing the channels. The sensitivity to 5-hydroxytryptamine orapomorphine depended on subunit combinations. When concentration-response relationship was obtained for the acetylcholine-activated current. the maximal response was reduced by these compounds. The inhibition by these compounds exhibited voltage-dependence: the inhibition was augmented at negative potentials. The results suggest that 5-hydroxytryptamine and apomorphine noncompetitively inhibits human recombinant nicotinic acetylcholine receptor/channels, presumably by acting on channel pores. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:21:37