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Titolo:
STRIATAL AND EXTRASTRIATAL IMAGING OF DOPAMINE D-2 RECEPTORS IN THE LIVING HUMAN BRAIN WITH [I-123] EPIDEPRIDE SINGLE-PHOTON EMISSION TOMOGRAPHY
Autore:
KUIKKA JT; AKERMAN KK; HILTUNEN J; BERGSTROM KA; RASANEN P; VANNINEN E; HALLDIN C; TIIHONEN J;
Indirizzi:
KUOPIO UNIV HOSP,DEPT CLIN PHYSIOL FIN-70210 KUOPIO FINLAND MAP MED TECHNOL INC FIN-41160 TIKKAKOSKI FINLAND UNIV KUOPIO,DEPT FORENS PSYCHIAT FIN-70240 KUOPIO FINLAND NIUVANNIEMI HOSP FIN-70240 KUOPIO FINLAND KAROLINSKA INST,KAROLINSKA HOSP,DEPT CLIN NEUROSCI,PSYCHOL SECT S-17176 STOCKHOLM SWEDEN
Titolo Testata:
European journal of nuclear medicine
fascicolo: 5, volume: 24, anno: 1997,
pagine: 483 - 487
SICI:
0340-6997(1997)24:5<483:SAEIOD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-123; RADIOLIGAND; EPIDEPRIDE;
Keywords:
DOPAMINE D-2 RECEPTOR; EPIDEPRIDE; EXTRASTRIATAL; SINGLE-PHOTON EMISSION TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
J.T. Kuikka et al., "STRIATAL AND EXTRASTRIATAL IMAGING OF DOPAMINE D-2 RECEPTORS IN THE LIVING HUMAN BRAIN WITH [I-123] EPIDEPRIDE SINGLE-PHOTON EMISSION TOMOGRAPHY", European journal of nuclear medicine, 24(5), 1997, pp. 483-487

Abstract

The iodine-123 labelled ligand benzamide epidepride was evaluated as a probe for in vivo imaging of striatal and extrastriatal dopamine D-2receptor sites in the human brain. Four healthy males were imaged with a high-resolution single-photon emission tomography scanner. Striatal radioactivity peaked at 3 h after injection. The specific binding inthe striatum was 0.91+/-0.03 at 3 h and this ratio steadily increasedwith time. Extrastriatal radioactivity was highest in the thalamus, in the midbrain and in the temporal cortex, and peaked at 45-60 min after injection of tracer. A smaller amount of radioactivity was found inthe parietal, frontal and occipital cortices. Two radioactive metabolites were observed, of which one was more lipophilic than the parent compound. The radiation burden to the patient was 0.035 mSv/MBq (effective dose equivalent). The preliminary results showed that [I-123]epidepride can be used for imaging striatal and extrastriatal dopamine D-2 receptor sites in the living human brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:01:53