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Titolo:
The role of drug-paired stimuli in extinction and reinstatement of ethanol-seeking behaviour in the rat
Autore:
Bienkowski, P; Kostowski, W; Koros, E;
Indirizzi:
Inst Psychiat & Neurol, Dept Pharmacol & Physiol Nervous Syst, PL-02957 Warsaw, Poland Inst Psychiat & Neurol Warsaw Poland PL-02957 t, PL-02957 Warsaw, Poland Warsaw Med Univ, Dept Expt & Clin Pharmacol, PL-00927 Warsaw, Poland Warsaw Med Univ Warsaw Poland PL-00927 harmacol, PL-00927 Warsaw, Poland
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 374, anno: 1999,
pagine: 315 - 319
SICI:
0014-2999(19990625)374:3<315:TRODSI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL DEPENDENCE; RELAPSE;
Keywords:
ethanol self-administration; extinction; reinstatement; relapse; (rat);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Bienkowski, P Inst Psychiat & Neurol, Dept Pharmacol & Physiol Nervous Syst, Al Sobieskiego 1-9, PL-02957 Warsaw, Poland Inst Psychiat & Neurol Al Sobieskiego 1-9 Warsaw Poland PL-02957
Citazione:
P. Bienkowski et al., "The role of drug-paired stimuli in extinction and reinstatement of ethanol-seeking behaviour in the rat", EUR J PHARM, 374(3), 1999, pp. 315-319

Abstract

Male Wistar rats were trained to respond for ethanol (30 min/day) in an oral self-administration procedure. A single lever press resulted in presentation of 0.1 ml of 8% ethanol from a liquid dipper. When responding for ethanol stabilised, reinstatement sessions started. In the 30-min reinstatementsession, lever pressing was first extinguished for 20 min by switching thedipper off. Then. different kinds of stimuli were non-contingently delivered and reinstatement of lever pressing was assessed. Fifteen random (randomtime = 15 s) presentations of the dipper containing 8% ethanol potently reinstated ethanol-seeking. The reinstatement of lever pressing was immediateand most responses were emitted during the time needed for the first five presentations to occur. Presentations of the empty dipper or delivery of a non-specific stimulus (high-amplitude tone) did not produce any reinstatement. These results indicate that non-contingent presentations of the ethanol-associated stimulus complex may reinstate operant behaviour previously reinforced with ethanol. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 16/07/20 alle ore 06:41:02