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Titolo:
Mono- and plurihormonal thyrotropic pituitary adenomas: pathological, hormonal and clinical studies in 12 patients
Autore:
Bertholon-Gregoire, M; Trouillas, J; Guigard, MP; Loras, B; Tourniaire, J;
Indirizzi:
Hop Antiquaille, Clin Endocrinol, F-69321 Lyon 5, France Hop Antiquaille Lyon France 5 e, Clin Endocrinol, F-69321 Lyon 5, France Fac Med Lyon RTH Laennec, INSERM, U369, Lab Histol & Embryol Mol, F-69372 Lyon, France Fac Med Lyon RTH Laennec Lyon France F-69372 l Mol, F-69372 Lyon, France Ctr Hosp Lyon Sud, INSERM, U407, Lab Biochim B, F-69310 Pierre Benite, France Ctr Hosp Lyon Sud Pierre Benite France F-69310 310 Pierre Benite, France
Titolo Testata:
EUROPEAN JOURNAL OF ENDOCRINOLOGY
fascicolo: 6, volume: 140, anno: 1999,
pagine: 519 - 527
SICI:
0804-4643(199906)140:6<519:MAPTPA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; GROWTH-HORMONE; CELL-CULTURE; FOLLOW-UP; IN-VITRO; TUMORS; BIOACTIVITY; SECRETION; PROLACTIN; DIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Bertholon-Gregoire, M Hop Antiquaille, Clin Endocrinol, F-69321 Lyon 5, France Hop Antiquaille Lyon France 5 69321 Lyon 5, France
Citazione:
M. Bertholon-Gregoire et al., "Mono- and plurihormonal thyrotropic pituitary adenomas: pathological, hormonal and clinical studies in 12 patients", EUR J ENDOC, 140(6), 1999, pp. 519-527

Abstract

In a series of 12 patients (eight women and four men. aged between 30 and 62 years), operated on for a pituitary adenoma shown to be thyrotropic by immunocytochemistry, we performed a retrospective and comparative analysis of clinical and biological data, tumor studies including immunocytochemistrywith double labeling. and proliferation marker (proliferative cell nuclearantigen (PCNA) and Ki-67) detection, electron microscopy and culture. Our study leads us to confirm that thyrotropic tumors are rare (12 of 1174 pituitary adenomas: 1%). The main points arising were that: (1) high or normal plasma TSH associated with an increase in plasma a-subunit and high thyroidhormone levels is the best criterion for diagnosis; (2) the failure of TSHto respond to TRH or Werner's test is not a reliable criterion for diagnosis; (3) thyrotropic adenomas may be 'silent', without clinical signs of hyperthyroidism and with only slight increase in TSH, tri-iodothyronine and thyroxine concentrations; (4) mitoses and nuclear atypies are frequently detected in large tumors, which are invasive in more than 50% of cases - the first analysis of two proliferation markers (PCNA and Ki-67) bears out the relative aggressiveness of thyrotropic adenomas: (5) thyrotropic adenomas arefrequently plurihormonal. Immunocytochemical double labeling, complementedby in vitro study, showed that thyrotropic tumor cells sometimes can or sometimes cannot cosecrete TSH, GH or prolactin. The pathological identification of monohormonal and plurihormonal adenomas seems to be supported by clinical and biological differences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 07:59:33