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Titolo:
Screening for concomitant alcohol abuse in schizophrenia: Clinical significance of the Munich alcoholism test and laboratory tests
Autore:
Agelink, MW; Ullrich, H; Lemmer, W; Dirkes-Kersting, A; Zeit, T;
Indirizzi:
Ruhr Univ Bochum, Evangelical Hosp Gelsenkirchen, Dept Psychiat, D-45879 Gelsenkirchen, Germany Ruhr Univ Bochum Gelsenkirchen Germany D-45879 79 Gelsenkirchen, Germany Inst Hyg, Gelsenkirchen, Germany Inst Hyg Gelsenkirchen GermanyInst Hyg, Gelsenkirchen, Germany
Titolo Testata:
EUROPEAN ADDICTION RESEARCH
fascicolo: 2, volume: 5, anno: 1999,
pagine: 82 - 87
SICI:
1022-6877(199906)5:2<82:SFCAAI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBOHYDRATE-DEFICIENT TRANSFERRIN; GAMMA-GLUTAMYL-TRANSFERASE; SUBSTANCE ABUSE; QUESTIONNAIRE; CONSUMPTION; DRINKING; MAST; PREVALENCE; DIAGNOSIS; DISORDERS;
Keywords:
schizophrenia; comorbidity; dual diagnosis; alcohol; alcoholism; carbohydrate-deficient transferrin; gamma glutamyltransferase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Agelink, MW Ruhr Univ Bochum, Evangelical Hosp Gelsenkirchen, Dept Psychiat, Munckelstr 27, D-45879 Gelsenkirchen, Germany Ruhr Univ Bochum Munckelstr 27 Gelsenkirchen Germany D-45879
Citazione:
M.W. Agelink et al., "Screening for concomitant alcohol abuse in schizophrenia: Clinical significance of the Munich alcoholism test and laboratory tests", EUR ADDIC R, 5(2), 1999, pp. 82-87

Abstract

For the early and correct diagnosis of the comorbidity of schizophrenia and alcoholism, a valid laboratory marker would be most helpful in clinical practice. Seventy schizophrenics admitted to a general psychiatric unit of an urban hospital located in a large industrial area in Germany prospectively underwent a detailed addiction history, the Munich Alcoholism Test (MALT)and determinations of serum gamma-glutamyltransferase (gamma GT) and carbohydrate-deficient transferrin (CDT). Cutoff levels for laboratory tests represented the 95th percentile of data obtained from 100 matched healthy controls. Using the MALT, we found evidence of concomitant alcohol consumption in 42.8% of the study patients. The sensitivities of gamma GT and CDT for detecting alcohol abuse (confirmed using DSM III-R criteria) were 70.6 and 58.8%, respectively. Our data suggest that the MALT can be used as a reliable screening test for alcohol use in schizophrenia. In neuroleptic-treated schizophrenics with pathological gamma GT, but low MALT scores, the corresponding CDT may serve as a highly specific marker to verify a concomitant alcohol abuse.

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Documento generato il 09/04/20 alle ore 07:34:27