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Titolo:
[F-18]FDG-PET and whole-scalp MEG localization of epileptogenic cortex
Autore:
Lamusuo, S; Forss, N; Ruottinen, HM; Bergman, J; Makela, JP; Mervaala, E; Solin, O; Rinne, JK; Ruotsalainen, U; Ylinen, A; Vapalahti, M; Hari, R; Rinne, JO;
Indirizzi:
Univ Turku, Dept Neurol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 Dept Neurol, FIN-20520 Turku, Finland Helsinki Univ Technol, Low Temp Lab, Brain Res Unit, Helsinki, Finland Helsinki Univ Technol Helsinki Finland rain Res Unit, Helsinki, Finland Abo Akad Univ, Accelerator Lab, Turku, Finland Abo Akad Univ Turku Finland Akad Univ, Accelerator Lab, Turku, Finland Univ Kuopio, Dept Clin Neurophysiol, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 ophysiol, FIN-70211 Kuopio, Finland Univ Kuopio, Dept Neurosurg, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 eurosurg, FIN-70211 Kuopio, Finland Turku PET Ctr, Turku, Finland Turku PET Ctr Turku FinlandTurku PET Ctr, Turku, Finland Univ Kuopio, Dept Neurol, Kuopio, Finland Univ Kuopio Kuopio FinlandUniv Kuopio, Dept Neurol, Kuopio, Finland
Titolo Testata:
EPILEPSIA
fascicolo: 7, volume: 40, anno: 1999,
pagine: 921 - 930
SICI:
0013-9580(199907)40:7<921:[AWMLO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; POSITRON EMISSION TOMOGRAPHY; CEREBRAL GLUCOSE-METABOLISM; FDG-PET; HUMAN-BRAIN; PARTIAL SEIZURES; DEPTH-ELECTRODE; MAGNETIC-FIELDS; VOLUMETRIC MRI; F-18 FDG;
Keywords:
[F-18]FDG-PET; PET; MEG; epilepsy; epilepsy surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Lamusuo, S Univ Turku, Dept Neurol, FIN-20520 Turku, Finland Univ Turku Turku Finland FIN-20520 , FIN-20520 Turku, Finland
Citazione:
S. Lamusuo et al., "[F-18]FDG-PET and whole-scalp MEG localization of epileptogenic cortex", EPILEPSIA, 40(7), 1999, pp. 921-930

Abstract

Purpose: To evaluate combined [F-18]fluorodeoxyglucose (F-18-FDG) positronemission tomography (PET) and 122-channel whole-scalp magnetoencephalography (MEG) in lateralizing the epileptogenic cortex in patients whose routinepresurgical evaluations gave discordant results about the location of the epileptic focus. Methods: Nine patients (five women, four men) aged 13-40 years were studied. Subdural EEG (SEEG) was recorded from eight patients. Six patients were operated on. Results: In seven of nine patients, PET and MEG agreed in localizing the epileptogenic cortex. When PET and MEG were in congruence, SEEG agreed with the findings. In five of six operated-on patients, PET and MEG results werecongruent, and the outcome of the operation was successful. Two patients had discordant PET and MEG results. In one patient, PET showed bitemporal hypometabolism, whereas MEG showed epileptiform activity in the right parietal lobe. The surgical outcome of the palliative temporal lobectomy was poor. Another patient had unilateral temporal hypometabolism in PET and bitemporal activity in MEG. She was not operated on. Conclusions: In most patients, PET and MEG were congruent in locating the epileptogenic cortex. Thus the combination of these techniques may provide useful support for the localization of the seizure onset and reduce the need for invasive procedures.

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Documento generato il 31/03/20 alle ore 16:18:37