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Titolo:
Tandem-base mutations occur in mouse liver and adipose tissue preferentially as G : C to T : A transversions and accumulate with age
Autore:
Buettner, VL; Hill, KA; Halangoda, A; Sommer, SS;
Indirizzi:
City Hope Natl Med Ctr, Beckman Res Inst, Dept Mol Genet, Duarte, CA 91010USA City Hope Natl Med Ctr Duarte CA USA 91010 Mol Genet, Duarte, CA 91010USA
Titolo Testata:
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
fascicolo: 4, volume: 33, anno: 1999,
pagine: 320 - 324
SICI:
0893-6692(1999)33:4<320:TMOIML>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LACI TRANSGENIC MICE; DOUBLE CC->TT MUTATIONS; DNA-POLYMERASE-BETA; SHUTTLE VECTOR; GENE-MUTATIONS; BREAST-CANCER; SPECTRUM; FREQUENCIES; INDUCTION;
Keywords:
diet; mutagen; lipophilic mutagen; spontaneous mutation; breast cancer; lacl transgene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Sommer, SS City Hope Natl Med Ctr, Beckman Res Inst, Dept Mol Genet, 1500 E Duarte Rd, Duarte, CA 91010 USA City Hope Natl Med Ctr 1500 E Duarte Rd Duarte CA USA 91010 USA
Citazione:
V.L. Buettner et al., "Tandem-base mutations occur in mouse liver and adipose tissue preferentially as G : C to T : A transversions and accumulate with age", ENV MOL MUT, 33(4), 1999, pp. 320-324

Abstract

Tandem-base mutations (TBM) are associated with ultraviolet light and other mutagens. Herein, we report an age- and tissue-specific difference in thefrequency of spontaneous TBM in Big Blue(R) transgenic mice. A total of 390 mutants from liver and adipose tissue contained 17 and 4 TBM, respectively, while no TBM were detected in 683 mutants from six other tissues. There was a proportional increase in the frequency of TBM in liver with age (29 days postconception to 25 months of age). Nine TBM (43%) were GG to TT transversions that preferentially occurred at specific sites. The remaining 12 mutants contained at least one transversion mutation each, We speculate thatthe increase of TBM in liver and adipose tissue with age is due to chronicmutagen exposure, perhaps derived From fat in the diet. Environ. Mol. Mutagen. 33: 320-324, 1999 (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:39:19