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Titolo:
Association between the biological characteristics of HIV-1, vertical transmission of infection and clinical progression of pediatric disease
Autore:
Andiman, WA;
Indirizzi:
Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 ed, Dept Pediat, New Haven, CT 06520 USA
Titolo Testata:
CURRENT OPINION IN INFECTIOUS DISEASES
fascicolo: 3, volume: 12, anno: 1999,
pagine: 239 - 244
SICI:
0951-7375(199906)12:3<239:ABTBCO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; SYNCYTIUM-INDUCING PHENOTYPE; TO-CHILD TRANSMISSION; MONOCYTE-MACROPHAGES; CHEMOKINE RECEPTORS; VIRAL PHENOTYPE; TYPE-1; INFANTS; CELLS; LOAD;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Andiman, WA Yale Univ, Sch Med, Dept Pediat, 333 Cedar St, New Haven, CT 06520 USA Yale Univ 333 Cedar St New Haven CT USA 06520 en, CT 06520 USA
Citazione:
W.A. Andiman, "Association between the biological characteristics of HIV-1, vertical transmission of infection and clinical progression of pediatric disease", CURR OPIN I, 12(3), 1999, pp. 239-244

Abstract

The design of effective prophylactic measures to prevent the vertical transmission of HIV-1 and of therapies to alter the natural progression of pediatric HIV disease requires a thorough understanding of basic pathogenetic principles. Maternal viral load, the biological behavior of HIV, such as replicative capacity in different types of cells, monocyte/macrophage tropism,and the capacity of the infant's cells to support infection have all been assessed for their contribution to the risk of mother-to-child transmission. Similarly, the effects of viral load and phenotype (e.g. replicative capacity, cell tropism, syncytium-inducing capacity and the use of chemokine co-receptors) have all been investigated as parameters associated with variations in the expression of clinical disease in children. Some of the extant data are conflicting, but general principles regarding pathogenesis are beginning to emerge. Curr Opin Infect Dis 12:239-244. (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 14:48:34