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Titolo:
Combined effects of inhaled nitric oxide and hyperoxia on pulmonary vascular permeability and lung mechanics
Autore:
Storme, L; Riou, Y; Dubois, A; Fialdes, P; Jaillard, S; Klosowski, S; Dupuis, B; Lequien, P;
Indirizzi:
CHU Lille, Dept Neonatol, F-59037 Lille, France CHU Lille Lille France F-59037 lle, Dept Neonatol, F-59037 Lille, France CHU Lille, Dept Physiol, F-59037 Lille, France CHU Lille Lille France F-59037 ille, Dept Physiol, F-59037 Lille, France CHU Lille, Dept Nucl Med, F-59037 Lille, France CHU Lille Lille France F-59037 lle, Dept Nucl Med, F-59037 Lille, France CHU Lille, Dept Thorac Surg, F-59037 Lille, France CHU Lille Lille France F-59037 , Dept Thorac Surg, F-59037 Lille, France CHU Lille, Dept Expt Pharmacol, F-59037 Lille, France CHU Lille Lille France F-59037 ept Expt Pharmacol, F-59037 Lille, France
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 6, volume: 27, anno: 1999,
pagine: 1168 - 1174
SICI:
0090-3493(199906)27:6<1168:CEOINO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACTANT DYSFUNCTION; INJURY; SUPEROXIDE; NEWBORN; EDEMA; FLUID; INHALATION; INHIBITION; RESISTANCE; PREVENTS;
Keywords:
nitric oxide; oxidative stress; pulmonary vascular permeability; respiratory mechanics; gas exchange; newborns;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Lequien, P CHU Lille, Hop Jeanne de Flandre, Serv Med Neonatale, F-59037 Lille, France CHU Lille Lille France F-59037 onatale, F-59037 Lille, France
Citazione:
L. Storme et al., "Combined effects of inhaled nitric oxide and hyperoxia on pulmonary vascular permeability and lung mechanics", CRIT CARE M, 27(6), 1999, pp. 1168-1174

Abstract

Objective: To determine whether inhaled nitric oxide (NO) may alter pulmonary vascular permeability and respiratory function in an in vivo model. Design: Prospective, randomized, controlled, experimental study. Setting: University experimental pharmacology laboratory. Subjects: Mechanically ventilated newborn piglets, 1 to 2 days old, exposed to 100% oxygen for 76 hrs. Interventions: The piglets were randomly assigned either to a treatment group receiving 20 ppm inhaled NO from the onset of ventilation (n = 5) or toa control group (n = 6) receiving no treatment. Measurements and Main Results: The main variables studied were gas exchange (Pao(2)/F10(2) ratio, lung diffusing capacity), respiratory mechanics (static compliance of the respiratory system, stat, quasi-static hysteresis area, functional residual capacity), and pulmonary vascular permeability assessed by simultaneous intravenous administration of iodine-125-labeled albumin and chromium-51-labeled red blood cells. Extravascular albumin space of the lung and dry lung weight were significantly higher in the NO group vs. the control group (albumin space, 1.08 +/- 0.16 vs. 0.70 +/- 0.26 [SD] mL/kg body weight [p < .05]; dry lung weight, 3.20 +/- 0.34 vs. 2.66 +/- 0.14 g/kg body weight [p < .05]). Moreover, the hysteresis area was higher from 24 hrs of NO exposure. Conversely, NO inhalation altered neither the extravascular lung water content (12.98 +/- 2.79 mL/kg body weight in the NO groupvs. 12.18 +/- 2.26 mL/kg body weight in the control group [not significant]) nor the main respiratory mechanical variables (static compliance, functional residual capacity) and gas exchange (lung diffusing capacity, Pao(2)/F10(2) ratio). Conclusion: These results do not support the hypothesis that NO inhalationcombined with hyperoxia can alter the main lung-function variables in neonates. However, it may induce an increase in lung vascular protein leakage. The pathophysiologic consequences of this finding remain to be elucidated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:07:05