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Titolo:
Serum cystatin C as an endogenous marker of the renal function - a review
Autore:
Randers, E; Erlandsen, EJ;
Indirizzi:
Viborg Hosp, Dept Internal Med, DK-8800 Viborg, Denmark Viborg Hosp Viborg Denmark DK-8800 Internal Med, DK-8800 Viborg, Denmark Viborg Hosp, Dept Clin Biochem, Viborg, Denmark Viborg Hosp Viborg Denmark org Hosp, Dept Clin Biochem, Viborg, Denmark
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 4, volume: 37, anno: 1999,
pagine: 389 - 395
SICI:
1434-6621(199904)37:4<389:SCCAAE>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; CYSTEINE PROTEINASE-INHIBITORS; HUMAN GAMMA-TRACE; MOLECULAR-WEIGHT PROTEINS; ALVEOLAR MACROPHAGES; REFERENCE INTERVALS; BIOLOGICAL-FLUIDS; SENSITIVE MARKER; REFERENCE VALUES; CATHEPSIN-B;
Keywords:
creatinine; cysteine proteinase inhibitors; glomerular filtration rate; immunoassay; kidney function tests;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Randers, E Viborg Hosp, Dept Internal Med, Heibergs Alle 4, DK-8800 Viborg, Denmark Viborg Hosp Heibergs Alle 4 Viborg Denmark DK-8800 rg, Denmark
Citazione:
E. Randers e E.J. Erlandsen, "Serum cystatin C as an endogenous marker of the renal function - a review", CLIN CH L M, 37(4), 1999, pp. 389-395

Abstract

Since 1985, cystatin C has been suggested to be a marker of the renal function. Cystatin C is a proteinase inhibitor with a low molecular weight (M-r= 13359). It is produced at a constant rate in all nucleated cells investigated to date, freely filtered in the renal glomeruli and reabsorbed and catabolised in the proximal tubules. The concentration of serum cystatin C ismainly determined by glomerular filtration, which makes cystatin C an endogenous marker of glomerular filtration rate (GFR). There are few data describing the influence of various factors on the production and elimination ofcystatin C. Fully automated assays using particle-enhanced turbidimetry orparticle-enhanced nephelometry are available and the assays are precise, rapid and usable in clinical routine practice. Reference intervals have beendetermined for cystatin C in adults and in children older than one year. It has been suggested that the same reference interval can be used in children older than one year and in adults without gender differences, on the assumption that the same method with the same standardisation is used. Severalstudies including adults and children with different renal diseases with various kidney function have suggested serum cystatin C to be a better marker of GFR than serum creatinine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 09:58:08