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Titolo:
Heparin lowers plasma levels of activated factor VII
Autore:
Pernerstorfer, T; Jilma, B; Eichler, HG; Aull, S; Handler, S; Speiser, W;
Indirizzi:
Univ Vienna, Dept Clin Pharmacol TARGET, Vienna, Austria Univ Vienna Vienna Austria Dept Clin Pharmacol TARGET, Vienna, Austria Univ Vienna, Dept Neurol, Vienna, Austria Univ Vienna Vienna AustriaUniv Vienna, Dept Neurol, Vienna, Austria Univ Vienna, Clin Inst Med & Chem Lab Diagnost, Vienna, Austria Univ Vienna Vienna Austria nst Med & Chem Lab Diagnost, Vienna, Austria
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 4, volume: 105, anno: 1999,
pagine: 1127 - 1129
SICI:
0007-1048(199906)105:4<1127:HLPLOA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; HEART-DISEASE; TISSUE FACTOR; DECREASE;
Keywords:
heparin; FVIIa; FVII antigen; FVII activity; prothrombin fragment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Pernerstorfer, T Univ Hosp Vienna, Sch Med, Dept Clin Pharmacol TARGET, Wahringer Gurtel 18-20, A-1090 Vienna, Austria Univ Hosp Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090
Citazione:
T. Pernerstorfer et al., "Heparin lowers plasma levels of activated factor VII", BR J HAEM, 105(4), 1999, pp. 1127-1129

Abstract

Based on heparin's antithrombin and anti-FXa activity and its in vitro inhibition of activated factor VII (FVIIa) activity, we hypothesized that unfractionated heparin (UFH) may decrease plasma levels of FVIIa in humans. Therefore, 10 healthy young male volunteers received an intravenous UFH infusion over 24 h. Heparin decreased FVIIa levels by 30% (95% CI 14-47%) at 12 h, which was sustained until 24 h, In contrast, neither the substrate pool (i.e. total factor VII) as measured by FVII antigen nor FVII activity were affected by UFH, These results may improve our understanding of the regulation of FVIIa levels and heparin's mode of action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:54:44