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Titolo:
Molecular epidemiological study of non-small-cell lung cancer from an environmentally polluted region of Poland
Autore:
Rusin, M; Butkiewicz, D; Malusecka, E; Zborek, A; Harasim, J; Czyzewski, K; Bennett, WP; Shields, PG; Weston, A; Welsh, JA; Krzyzowska-Gruca, S; Chorazy, M; Harris, CC;
Indirizzi:
NCI, Human Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA Silesian Acad Med, Dept Thorac Surg, PL-41800 Zabrze, Poland Silesian AcadMed Zabrze Poland PL-41800 c Surg, PL-41800 Zabrze, Poland NCI, Human Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA Inst Oncol, Dept Tumor Biol, PL-44100 Gliwice, Poland Inst Oncol GliwicePoland PL-44100 Tumor Biol, PL-44100 Gliwice, Poland
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 9, volume: 80, anno: 1999,
pagine: 1445 - 1452
SICI:
0007-0920(199907)80:9<1445:MESONL>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDROCARBON-DNA ADDUCTS; TUMOR-SUPPRESSOR GENE; S-TRANSFERASE GENES; GSTM1 NULL GENOTYPE; P53 MUTATIONS; POOR METABOLIZERS; STRAND BIAS; COAL-MINERS; SUSCEPTIBILITY; EXPOSURE;
Keywords:
p53; WAF1; GSTM1; CYP1A1; CYP2D6; tobacco smoke;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Harris, CC NCI, Human Carcinogenesis Lab, NIH, Bldg 37, Bethesda, MD 20892USA NCI Bldg 37 Bethesda MD USA 20892 dg 37, Bethesda, MD 20892 USA
Citazione:
M. Rusin et al., "Molecular epidemiological study of non-small-cell lung cancer from an environmentally polluted region of Poland", BR J CANC, 80(9), 1999, pp. 1445-1452

Abstract

The p53 mutation spectrum can generate hypotheses linking carcinogen exposure to human cancer. Although it is well-documented that tobacco smoking isa major cause of lung cancer, the contribution of air pollution is less well-established. We determined the molecular and immunohistochemical changes(p53 gene mutations, p53 protein accumulation and WAF1 protein expression)and genetic polymorphisms of GSTM1, CYP1A1 and CYP2D6 genes in a case series of non-small-cell lung cancers from Silesia. This region of southern Poland is highly industrialized with considerable environmental pollution. More than 50% of lung cancers (90/164) contained p53 mutations and 75% showed the combined alteration of the p53 gene and protein accumulation. Males occupationally exposed to coal-derived substances showed a relatively high frequency of squamous and large-cell carcinomas, relatively frequent mutationsin codon 298 of p53 and a low frequency of p53 immunohistochemically positive tumours. Codon 298 GAG--> TAG mutations have rarely been found in lung cancers in other populations. We found no correlation between WAF1 protein expression and mutations in the p53 gene or p53 protein accumulation. No statistically significant relationship was found between p53 mutations and GSTM1, CYP1A1, CYP2D6 genotypes. Never smokers with lung cancers from Silesiahad a higher frequency of G:C--> T:A transversions than previously reported of the p53 mutation spectrum in never smokers (6/15 vs 4/34; P = 0.06 by chi(2)). These data are a tentative indication that occupational and environmental exposure to polycyclic aromatic hydrocarbons, such as benzo(a)pyrene, in polluted air contributes to the molecular pathogenesis of lung cancerin never smokers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:05:39