Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Enhancement of prepulse inhibition after blockade of GABA activity within the superior colliculus
Autore:
Fendt, M;
Indirizzi:
Univ Tubingen, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 bingen, D-72076 Tubingen, Germany
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 833, anno: 1999,
pagine: 81 - 85
SICI:
0006-8993(19990626)833:1<81:EOPIAB>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEDUNCULOPONTINE TEGMENTAL NUCLEUS; ACOUSTIC STARTLE RESPONSE; INFERIOR COLLICULUS; RAT; LESIONS; REFLEX; PROJECTIONS; PICROTOXIN; RECEPTOR; NEURONS;
Keywords:
acoustic startle response; GABA; picrotoxin; prepulse inhibition; rat; schizophrenia; sensorimotor gating; superior colliculus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Fendt, M Univ Tubingen, Morgenstelle 28, D-72076 Tubingen, Germany Univ Tubingen Morgenstelle 28 Tubingen Germany D-72076 , Germany
Citazione:
M. Fendt, "Enhancement of prepulse inhibition after blockade of GABA activity within the superior colliculus", BRAIN RES, 833(1), 1999, pp. 81-85

Abstract

The present study examined the effects of local microinjections of the GABA chloride channel blocker Picrotoxin into the superior colliculus (SC) on prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats. PPI is a useful model for the investigation of the neuronal basis of sensorimotor gating which is deficient in some psychiatric disorders, such as schizophrenia. Blockade of GABA activity within the SC by Picrotoxin injections(leading to a moderate stimulation of the SC) significantly enhanced PPI without affecting the ASR baseline amplitude or the spontaneous motor activity. Based on these results we discuss the role of the SC in a hypothetical neuronal circuit mediating PPI of the ASR. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 10:44:01