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Titolo:
THE CARDIOVASCULAR STARTLE RESPONSE - ANXIETY AND THE BENZODIAZEPINE RECEPTOR COMPLEX
Autore:
BERNTSON GG; HART S; SARTER M;
Indirizzi:
OHIO STATE UNIV,DEPT PSYCHOL & NEUROSCI PROGRAM,48 TOWNSHEND HALL COLUMBUS OH 43210
Titolo Testata:
Psychophysiology
fascicolo: 3, volume: 34, anno: 1997,
pagine: 348 - 357
SICI:
0048-5772(1997)34:3<348:TCSR-A>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTTRAUMATIC-STRESS-DISORDER; FEAR-POTENTIATED STARTLE; PARTIAL INVERSE AGONIST; HEART-RATE; BETA-CARBOLINE; PREPULSE INHIBITION; ACOUSTIC STARTLE; PHYSIOLOGICAL-RESPONSES; ANXIOGENIC PROPERTIES; BAROREFLEX CONTROL;
Keywords:
ACOUSTIC STARTLE REFLEX; BENZODIAZEPINE RECEPTOR; CARDIOVASCULAR RESPONSE; FG 7142; HEART RATE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
89
Recensione:
Indirizzi per estratti:
Citazione:
G.G. Berntson et al., "THE CARDIOVASCULAR STARTLE RESPONSE - ANXIETY AND THE BENZODIAZEPINE RECEPTOR COMPLEX", Psychophysiology, 34(3), 1997, pp. 348-357

Abstract

Benzodiazepine receptor (BZR) agonists are prototypic anxiolytic agents, whereas BZR inverse agonists exert anxiogenic effects. The effectsof these compounds offer a potentially important pharmacological model system to examine the central mechanisms of anxiety. In accord with its putative anxiogenic properties, we previously found that the BZR partial inverse agonist, FG 7142, enhances the cardiovascular defensiveresponse to a nonsignal acoustic stimulus in rats. In contrast, we found in the present study that this agent attenuates both the somatic and cardiovascular components of the acoustic startle response. BZR agonists and inverse agonists are known to modulate the basal forebrain cortical cholinergic system, and we consider the potential involvement of this system in the disparate psychophysiological actions of FG 7142and in anxiety states in general.

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Documento generato il 22/01/20 alle ore 09:22:28