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Titolo:
The role of chemotherapy in intracranial germinoma: A case report
Autore:
Hupperets, PSGJ; Defesche, HF; de Bruijckere, LM; Twijnstra, A;
Indirizzi:
Univ Hosp Maastricht, Dept Internal Med, Div Haematol Oncol, Sect HaematolOncol, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht MaastrichtNetherlands NL-6202 AZ icht, Netherlands Univ Hosp Maastricht, Dept Neurosurg, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht Maastricht Netherlands NL-6202 AZ icht, Netherlands Univ Hosp Maastricht, Dept Pathol, NL-6202 AZ Maastricht, Netherlands UnivHosp Maastricht Maastricht Netherlands NL-6202 AZ icht, Netherlands Univ Hosp Maastricht, Dept Neurol, NL-6202 AZ Maastricht, Netherlands UnivHosp Maastricht Maastricht Netherlands NL-6202 AZ icht, Netherlands
Titolo Testata:
ANNALS OF ONCOLOGY
fascicolo: 6, volume: 10, anno: 1999,
pagine: 723 - 726
SICI:
0923-7534(199906)10:6<723:TROCII>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GERM-CELL TUMORS; CENTRAL-NERVOUS-SYSTEM; RADIATION-THERAPY; IRRADIATION; MANAGEMENT; CHILDREN; TRIAL;
Keywords:
BEP chemotherapy; embryonal carcinoma testis; germinoma; pineal gland;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Hupperets, PSGJ Univ Hosp Maastricht, Dept Internal Med, Div Haematol Oncol, Sect HaematolOncol, POB 5800, NL-6202 AZ Maastricht, Netherlands Univ Hosp Maastricht POB 5800 Maastricht Netherlands NL-6202 AZ
Citazione:
P.S.G.J. Hupperets et al., "The role of chemotherapy in intracranial germinoma: A case report", ANN ONCOL, 10(6), 1999, pp. 723-726

Abstract

Background: The case of a 29-year-old man with histologically proven simultaneous germinoma (seminoma) of the pineal gland and a stage I embryonal carcinoma of the testis is reported. An intradural metastatic lesion from thepineal germinoma was diagnosed at the level of the first thoracic vertebra. Treatment, after inguinal orchiectomy, was chemotherapy only, rather thanconventional radiotherapy for the pineal germinoma. Methods: Therapy consisted of bleomycin (B), etoposide (E) and cisplatin (P). MRI was used to assess the effectiveness of BEP chemotherapy. Results: A complete remission of the pineal gland germinoma and the epidural metastasis was documented after two cycles of BEP chemotherapy and after15 months of follow-up the patient remains free of relapse. Discussion: The pathogenesis of simultaneously occurring germinoma of the pineal gland and embryonal cell carcinoma of the testis is discussed. The choice of therapy in these circumstances is a matter of debate and thegood result of chemotherapy alone in this patient suggest that primary chemotherapy may be the therapy of choice in patients with pineal germinomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:48:11