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Titolo:
Oncocytoid renal cell carcinoma after neuroblastoma: A report of four cases of a distinct clinicopathologic entity
Autore:
Medeiros, LJ; Palmedo, G; Krigman, HR; Kovacs, G; Beckwith, JB;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 c Ctr, Dept Pathol, Houston, TX 77030 USA Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77550 USA Univ Texas Galveston TX USA 77550 h, Dept Pathol, Galveston, TX 77550 USA Univ Heidelberg, Dept Urol, D-6900 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-6900 ol, D-6900 Heidelberg, Germany Loma Linda Univ, Sch Med, Dept Pathol, Loma Linda, CA USA Loma Linda UnivLoma Linda CA USA h Med, Dept Pathol, Loma Linda, CA USA
Titolo Testata:
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
fascicolo: 7, volume: 23, anno: 1999,
pagine: 772 - 780
SICI:
0147-5185(199907)23:7<772:ORCCAN>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMPARATIVE GENOMIC HYBRIDIZATION; MICROSATELLITE ANALYSIS; TUMORS; CHILDREN; NEOPLASMS; FEATURES; VARIANTS;
Keywords:
renal cell carcinoma; neuroblastoma; electron microscopy; immunohistochemistry; cytogenetics; polymerase chain reaction; microsatellite analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Medeiros, LJ Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Box 85,1515 Holcombe Blvd, Houston, TX 77030 USA Univ Texas Box 85,1515 Holcombe Blvd Houston TX USA 77030 USA
Citazione:
L.J. Medeiros et al., "Oncocytoid renal cell carcinoma after neuroblastoma: A report of four cases of a distinct clinicopathologic entity", AM J SURG P, 23(7), 1999, pp. 772-780

Abstract

Four children who developed oncocytoid renal cell carcinoma (RCC) after neuroblastoma are reported. One patient had multiple, bilateral RCCs. The mean age at time of diagnosis of RCC was 8.8 years (range, 5-13 years). The mean interval between neuroblastoma and RCC was 7.15 years (range, 3.1-11.5 years). The histologic findings of these RCCs did not fit within the spectrum of known renal epithelial neoplasms. Most of the neoplastic cells in all cases had eosinophilic, oncocytoid cytoplasm and were arranged in solid andpapillary growth patterns. A subset of cells with reticular cytoplasm was also present. Immunohistochemical studies demonstrated keratins 8 and 18 inall neoplasms and keratin 20 in two cases. DNA ploidy analysis revealed that two of three neoplasms assessed were aneuploid. Cytogenetic studies revealed 45, XX, add or dup (7)(q32q36) in one neoplasm, and 83-89, XXXX, -1,-3, del (3)(q11.1q2?1), der(4)t(4;?22) (q32;q11.2), -14, -22 in a second tumor. Microsatellite polymerase chain reaction analysis detected no abnormalities in one neoplasm and allelic imbalance of chromosomes 2p31-32.2, 8p22, 9p22-24, 13q22 20q13, and 22q11 in a second tumor. In case 4, two different RCCs excised 6 months apart were analyzed. The initial neoplasm showed allelic imbalance of chromosomes 2q31-32.2, 5q22, 5q31, 10p13-14, 13q22, 14q31,and 20q13. The subsequent neoplasm showed allelic imbalance of chromosomes3p21.3, 14q31, and 20q13. The common presence of 14q31 and 20q13 abnormalities suggests that these two neoplasms were genetically related. In aggregate, these findings are distinctive, are not found in known types of RCC, and support the morphologic impression that oncocytoid RCC after neuroblastoma is a distinct clinicopathologic entity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:59:35