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Titolo:
Normalization of information processing deficits in schizophrenia with clozapine
Autore:
Kumari, V; Soni, W; Sharma, T;
Indirizzi:
Inst Psychiat, Dept Psychol Med, Sect Cognit Psychopharmacol, London SE5 8AF, England Inst Psychiat London England SE5 8AF opharmacol, London SE5 8AF, England
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 7, volume: 156, anno: 1999,
pagine: 1046 - 1051
SICI:
0002-953X(199907)156:7<1046:NOIPDI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE-REFLEX; PREPULSE INHIBITION; ANIMAL-MODEL; SENSORIMOTOR; DISORDER; ANTIPSYCHOTICS; HYPERACTIVITY; HALOPERIDOL; HABITUATION; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Sharma, T Inst Psychiat, Dept Psychol Med, Sect Cognit Psychopharmacol, DeCrespignyPk, London SE5 8AF, England Inst Psychiat De Crespigny Pk LondonEngland SE5 8AF F, England
Citazione:
V. Kumari et al., "Normalization of information processing deficits in schizophrenia with clozapine", AM J PSYCHI, 156(7), 1999, pp. 1046-1051

Abstract

Objective: The authors tested the hypothesis that the use of an atypical drug, clozapine, for patients with schizophrenia is related to less impairment in information processing deficits (assessed by prepulse inhibition of the startle response) than is the use of typical antipsychotics. Method: Twogroups of schizophrenic patients-receiving either clozapine or a ran ge oftypical antipsychotics-we re tested for prepulse inhibition (a reduction in response to a startling stimulus, if preceded briefly by a weak, nonstartling stimulus; measured at prepulse-to-pulse intervals of 30 msec, 60 msec,and 120 msec) of the acoustic startle response and compared with a group of healthy volunteers. Results: Patients receiving typical antipsychotics showed less prepulse inhibition with 30-msec and 60-msec prepulse trials thandid comparison subjects. Clozapine-treated patients showed normal levels of prepulse inhibition. Conclusions: Clozapine is superior to typical antipsychotics in normalizing prepulse inhibition, presumably because of its pharmacological effects on prefrontal regions of the brain or its effects on a broader range of neuroreceptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 11:50:55