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Titolo:
Memory self-appraisal in middle-aged and older adults with the apolipoprotein e-4 allele
Autore:
Small, GW; Chen, ST; Komo, S; Ercoli, L; Bookheimer, S; Miller, K; Lavretsky, H; Saxena, S; Kaplan, A; Dorsey, D; Scott, WK; Saunders, AM; Haines, JL; Roses, AD; Pericak-Vance, MA;
Indirizzi:
Univ Calif Los Angeles, Inst Neuropsychiat, Alzheimers Dis Ctr, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Ctr Aging, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA VA Med Ctr, W Los Angeles, CA USA VA Med Ctr W Los Angeles CA USAVA Med Ctr, W Los Angeles, CA USA Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 iv, Med Ctr, Dept Med, Durham, NC 27710 USA Duke Univ, Med Ctr, Joseph & Kathleen Bryan Alzheimers Dis Res Ctr, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 lzheimers Dis Res Ctr, Durham, NC 27710 USA Glaxo Wellcome Res & Dev Ltd, Res Triangle Pk, NC USA Glaxo Wellcome Res &Dev Ltd Res Triangle Pk NC USA Triangle Pk, NC USA Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 & Biophys, Nashville, TN 37232 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 7, volume: 156, anno: 1999,
pagine: 1035 - 1038
SICI:
0002-953X(199907)156:7<1035:MSIMAO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; FUNCTIONING QUESTIONNAIRE; COGNITIVE IMPAIRMENT; ASSOCIATION; DIAGNOSIS; PERFORMANCE; INDIVIDUALS; COMPLAINTS; COMMUNITY; EPSILON-4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Small, GW Univ Calif Los Angeles, Inst Neuropsychiat, Alzheimers Dis Ctr, Dept Psychiat & Biobehav Sci, Room 88-201,760 Westwood Plaza, Los Angeles, CA 90024 USA Univ Calif Los Angeles Room 88-201,760 Westwood Plaza Los Angeles CA USA 90024
Citazione:
G.W. Small et al., "Memory self-appraisal in middle-aged and older adults with the apolipoprotein e-4 allele", AM J PSYCHI, 156(7), 1999, pp. 1035-1038

Abstract

Objective: Because subjective memory complaints may indicate subtle functional brain abnormalities, the authors studied the influence of the major genetic risk for Alzheimer's disease, the apolipoprotein E-4 (APOE-4) allele,on self-reports of memory performance in middle-aged and older adults. Method: Subjective and objective assessments of memory performance were compared in relation to the presence or absence of the APOE-4 allele in 39 cognitively intact persons with mild memory complaints. Results: Subjects with the APOE-4 allele had lower scores on objective verbal memory and on the subjective memory measure for retrospective functioning. Among the subjects in the age range where APOE-4 has its greatest influence on the risk of Alzheimer's disease (55-74 years), the APOE-4 group had lower scores on the subjective memory measure for frequency of forgetting. Moreover, the standardized difference in retrospective functioning scores between the two genetic risk groups increased when the mid-age-range group was examined rather than the whole study group. Conclusions: The APOE-4 allele is associated with increased subjective memory impairment in middle-aged and older adults. Longitudinal studies of age-related memory loss should include genetic risk and subjective memory measures as potential predictors of decline.

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Documento generato il 06/04/20 alle ore 02:56:43