Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall
Autore:
DiFederico, E; Genbacev, O; Fisher, SJ;
Indirizzi:
Univ Calif San Francisco, Dept Stomatol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco,CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco,CA 94143 USA Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
AMERICAN JOURNAL OF PATHOLOGY
fascicolo: 1, volume: 155, anno: 1999,
pagine: 293 - 301
SICI:
0002-9440(199907)155:1<293:PIAWWA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; ENDOVASCULAR INVASION; PRE-ECLAMPSIA; ADHESION; DIFFERENTIATION; PREGNANCY; BCL-2; PHENOTYPE; OXYGEN; LIFE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Fisher, SJ Univ Calif San Francisco, Dept Stomatol, HSW 604, San Francisco, CA 94143 USA Univ Calif San Francisco HSW 604 San Francisco CA USA 94143 USA
Citazione:
E. DiFederico et al., "Preeclampsia is associated with widespread apoptosis of placental cytotrophoblasts within the uterine wall", AM J PATH, 155(1), 1999, pp. 293-301

Abstract

Preeclampsia is a serious pregnancy complication diagnosed by signs of widespread maternal endothelial dysfunction. In normal pregnancy, a subpopulation of placental cytotrophoblast stem cells executes an unusual differentiation program that leads to invasion of the uterus and its vasculature. Thisprocess attaches the conceptus to the uterine wall and starts the flow of maternal blood to the placenta. Preeclampsia is associated with abnormal cytotrophoblast differentiation, shallow invasion, and decreased blood flow to the placenta. To determine whether abnormal differentiation and/or hypoxia leads to cytotrophoblast apoptosis, we used the TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling) method to label DNA strand breaks in tissue sections of the placenta and the uterine wall to which it attaches. Control samples (n = 9) showed almost no apoptosis, but in samples from patients with preeclampsia, 15-50% of the cytotrophoblasts thatinvaded the uterine wall were labeled (8/9 samples). These same cells failed to stain for Bcl-2, a survival factor normally expressed by trophoblastsin both the placenta and the uterine wall. Our results show that preeclampsia is associated with widespread apoptosis of cytotrophoblasts that invadethe uterus. The magnitude of programmed cell death in this population may account for the sudden onset of symptoms in some patients, as well as the associated coagulopathies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:07:07