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Titolo:
Lack of association of angiotensin-converting enzyme (DID/II) and angiotensinogen M235T gene polymorphism with renal function among Chinese patients with type II diabetes
Autore:
Wong, TYH; Chan, JCN; Poon, E; Li, PKT;
Indirizzi:
Chinese Univ Hong Kong, Dept Med & Therapeut, Prince Wales Hosp, Shatin, Hong Kong Chinese Univ Hong Kong Shatin Hong Kong e Wales Hosp, Shatin, Hong Kong
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 6, volume: 33, anno: 1999,
pagine: 1064 - 1070
SICI:
0272-6386(199906)33:6<1064:LOAOAE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSERTION DELETION POLYMORPHISM; MYOCARDIAL-INFARCTION; IDDM PATIENTS; PIMA-INDIANS; NEPHROPATHY; MELLITUS; DISEASE; NIDDM; COMPLICATIONS; ALBUMINURIA;
Keywords:
angiotensin 1-converting enzyme gene; angiotensinogen M235T gene; polymorphism; Chinese; type II diabetic nephropathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Li, PKT Chinese Univ Hong Kong, Dept Med & Therapeut, Prince Wales Hosp, Shatin, Hong Kong Chinese Univ Hong Kong Shatin Hong Kong Hosp, Shatin, Hong Kong
Citazione:
T.Y.H. Wong et al., "Lack of association of angiotensin-converting enzyme (DID/II) and angiotensinogen M235T gene polymorphism with renal function among Chinese patients with type II diabetes", AM J KIDNEY, 33(6), 1999, pp. 1064-1070

Abstract

The prevalence of diabetic nephropathy is greater in nonwhite patients with type II diabetes, including the Chinese, and genetic variation appears tohave a role. We examined angiotensin-converting enzyme (ACE) DD/II and angiotensinogen (Atg) M235T polymorphism in a cohort of Chinese patients with type II diabetes with an average duration of diabetes of 14 years. Group A (n = 88) did not have significant diabetic nephropathy (creatinine levels less than or equal to 130 mu mol/L [less than or equal to 1.48 mg/L], without macroalbuminuria), and group B (n = 80) had significant diabetic nephropathy (macroalbuminuria or creatinine level > 130 mu mol/L [> 1.48 mg/d], andthose undergoing dialysis). The two groups were matched in different aspects, including age, duration of diabetes, blood pressure, and glycemic control. The results showed: (1) no difference of genotype distribution between groups A and B (DD:DI:II, 14%:45%:41% v 8%:38%:54%; P = 0.20; TT:TM/MM, 70%:30% v 76%:24%; P = 0.43), (2) no evidence of synergistic effect of ACE (DD/II) and Atg M235T gene polymorphisms, (3) no difference of allele frequencies between groups A and B (D:I, 36%:64% v 27%:73%; P = 0.20 and I:RA, 86%:16% v 86%:14%; P = 0.73), and (4) ACE activity was greatest in patients with DD genotype and least in those with II genotype (DD:DI:II = 66.9 +/- 13.3U/L:61.5 +/- 19.9 U/L:45.0 +/- 17.0 U/L; P < 0.005). The data do not support a role of ACE (DD/II) or Atg M235T polymorphism in the development of diabetic nephropathy in Chinese patients with type II diabetes, and no synergistic effect was found between them. Greater ACE activity was associated with DD genotype, and its role in diabetic nephropathy remains to be elucidated. (C) 1999 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:20:12