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Titolo:
Rapidly developing T-cell posttransplantation lymphoproliferative disorder
Autore:
Kim, JY; Kim, CW; Ahn, C; Bang, YJ; Lee, HS;
Indirizzi:
Seoul Natl Univ, Coll Med, Dept Pathol, Chongno Gu, Seoul, South Korea Seoul Natl Univ Seoul South Korea athol, Chongno Gu, Seoul, South Korea Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea Seoul Natl Univ Seoul South Korea Dept Internal Med, Seoul, South Korea
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 1, volume: 34, anno: 1999,
pagine: E31 - E35
SICI:
0272-6386(199907)34:1<E31:RDTPLD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-TRANSPLANT RECIPIENT; ALLOGRAFT RECIPIENT; CYCLOSPORINE-A; DONOR ORIGIN; LYMPHOMA; IMMUNOSUPPRESSION; REJECTION; PATIENT; DISEASE; LIVER;
Keywords:
renal allograft; posttransplantation lymphoproliferative disorder; T cell; early onset;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, HS Seoul Natl Univ, Coll Med, Dept Pathol, Chongno Gu, Yongon Dong 28, Seoul,South Korea Seoul Natl Univ Yongon Dong 28 Seoul South Korea oul,South Korea
Citazione:
J.Y. Kim et al., "Rapidly developing T-cell posttransplantation lymphoproliferative disorder", AM J KIDNEY, 34(1), 1999, pp. E31-E35

Abstract

Posttransplantation lymphoproliferative disorder (PTLD) of T-cell origin has been rarely described in chronically immunosuppressed allograft recipients. We report a case of renal PTLD of a T lineage that occurred shortly after transplantation under a triple-immunosuppressive regimen. Renal graft biopsy performed 58 days posttransplantation showed extensive interstitial infiltrates of polymorphic lymphoid cells, which expressed the UCHL-1 and CD3markers for T-cell lineage. The clonal nature of the T cells in renal tissue was identified by showing rearrangement of the T-cell receptor gamma chain genes using a polymerase chain reaction (PCR). DNA extracted from the graft biopsy specimen did not show the sequences of human T-cell leukemia virus type 1 (HTLV-I) by PCR, Signals for Epstein-Barr virus (EBV) infection in renal tissue were not shown by in situ hybridization, After the reductionof immunosuppressive therapy, regression of PTLD lesion and development ofrejection were shown in the second graft biopsy and graftectomy specimen. The extreme rarity of rapidly developing T-cell PTLD in a renal allograft prompted us to write this report. (C) 1999 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:33:31