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Titolo:
Activation of renal pelvic chemoreceptors in rats: role of calcitonin gene-related peptide receptors
Autore:
Gontijo, JAR; Kopp, UC;
Indirizzi:
Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Med,Disciplina Med Interna, Lab Metab Hidrosalino Nucl Med & Cirurgia Expt, BR-13083970 Campinas,SP, Brazil Univ Estadual Campinas Campinas SP Brazil BR-13083970 BCmpinas,SP, Brazil Univ Iowa, Coll Med, Dept Internal Med, Iowa City, IA 52242 USA Univ IowaIowa City IA USA 52242 pt Internal Med, Iowa City, IA 52242 USA Dept Vet Affairs Med Ctr, Iowa City, IA 52242 USA Dept Vet Affairs Med Ctr Iowa City IA USA 52242 , Iowa City, IA 52242 USA
Titolo Testata:
ACTA PHYSIOLOGICA SCANDINAVICA
fascicolo: 2, volume: 166, anno: 1999,
pagine: 159 - 165
SICI:
0001-6772(199906)166:2<159:AORPCI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL-ROOT GANGLIA; SUBSTANCE-P; CAPSAICIN; ANTAGONIST; NEURONS; NERVES; TACHYKININS; RESPONSES; RELEASE; KIDNEY;
Keywords:
afferent renal nerve activity; calcitonin gene-related peptide; CGRP receptor antagonist; renal pelvic chemoreceptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Gontijo, JAR Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Med,Disciplina Med Interna, Lab Metab Hidrosalino Nucl Med & Cirurgia Expt, BR-13083970 Campinas,SP, Brazil Univ Estadual Campinas Campinas SP Brazil BR-13083970 BCazil
Citazione:
J.A.R. Gontijo e U.C. Kopp, "Activation of renal pelvic chemoreceptors in rats: role of calcitonin gene-related peptide receptors", ACT PHYSL S, 166(2), 1999, pp. 159-165

Abstract

Substance P and calcitonin gene-related peptide (CGRP) increase afferent renal nerve activity (ARNA). A substance P receptor antagonist but not a CGRP receptor antagonist, h-CGRP (8-37), blocks the ARNA response to renal mechanoreceptor (MRI stimulation. We have examined whether calcitonin gene-related peptide activates renal pelvic sensory receptors and whether such activation contributes to renal chemoreceptor stimulation. The calcitonin gene-related peptide receptor antagonist, h-CGRP (8-37) [0.01-10 mu mol L-1] dose-dependently decreased (29 +/- 4-86 +/- 13%, P < 0.01) the ipsilateral afferent renal nerve activity in response to the renal pelvic administration of calcitonin gene-related peptide (0.26 mu mol L-1). Renal pelvic perfusionwith 900 mM NaCl also increased ipsilateral ARNA (23 +/- 3% increase, P< 0.02) and contralateral urinary sodium excretion (13 +/- 4% increase, P < 0.05). However, these responses to hypertonic NaCl were unaltered by h-CGRP (8-37). Renal pelvic perfusion with 1 or 10 mu M h-CGRP (8-37) also failed to alter the ARNA responses to KCI (31.25, 62.5, and 125 mM). These results indicate that there are sensory receptors in the renal pelvic area that areresponsive to calcitonin gene-related peptide. The activation of these receptors elicits a contralateral natriuretic response. In contrast, the activation of renal calcitonin gene-related peptide receptors does not contribute to renal chemoreceptor activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 18:59:57