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Titolo:
Role of parvovirus B19 infection in childhood idiopathic thrombocytopenic purpura
Autore:
Heegaard, ED; Rosthoj, S; Petersen, BL; Nielsen, S; Pedersen, FK; Hornsleth, A;
Indirizzi:
Rigshosp, Dept Clin Microbiol 9301, Univ State Hosp, DK-2100 Copenhagen O,Denmark Rigshosp Copenhagen Denmark O v State Hosp, DK-2100 Copenhagen O,Denmark Rigshosp, Dept Pathol, Univ State Hosp, DK-2100 Copenhagen, Denmark Rigshosp Copenhagen Denmark DK-2100 te Hosp, DK-2100 Copenhagen, Denmark Rigshosp, Dept Pediat 2, Univ State Hosp, DK-2100 Copenhagen O, Denmark Rigshosp Copenhagen Denmark O State Hosp, DK-2100 Copenhagen O, Denmark Aalborg Hosp, Dept Pediat, Aalborg, Denmark Aalborg Hosp Aalborg Denmark alborg Hosp, Dept Pediat, Aalborg, Denmark
Titolo Testata:
ACTA PAEDIATRICA
fascicolo: 6, volume: 88, anno: 1999,
pagine: 614 - 617
SICI:
0803-5253(199906)88:6<614:ROPBII>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIENT ERYTHROBLASTOPENIA; PERIPHERAL-BLOOD; APLASTIC CRISIS; B-19 INFECTION; IMMUNODEFICIENCY; NEUTROPENIA; ASSOCIATION; ANTIBODIES; ANEMIA; VIRUS;
Keywords:
idiopathic thrombocytopenic purpura; immunoglobulin; parvovirus B19; polymerase chain reaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Heegaard, ED Rigshosp, Dept Clin Microbiol 9301, Univ State Hosp, Juliane Maries Vej 22, DK-2100 Copenhagen O, Denmark Rigshosp Juliane Maries Vej 22Copenhagen Denmark O Denmark
Citazione:
E.D. Heegaard et al., "Role of parvovirus B19 infection in childhood idiopathic thrombocytopenic purpura", ACT PAEDIAT, 88(6), 1999, pp. 614-617

Abstract

Although parvovirus B19 exhibits a strong tissue-tropism for erythroid progenitor cells leading to anaemia, several case reports indicate that parvovirus B19 infection may also cause the development of thrombocytopenia. Despite recent studies, the frequency and clinical relevance of this association have remained questionable. Consequently, and in view of the paucity of evidence regarding a viral aetiology for idiopathic thrombocytopenic purpura(ITP). we examined the role of parvovirus B19 in 47 children with newly diagnosed ITP, Specific viral DNA indicating a current or recent parvovirus B19 infection was demonstrated in 6 of 47 patients (13%) employing the polymerase chain reaction technique. Our study suggests that children with ITP and associated parvovirus B19 infection are characterized by acute onset of profound thrombocytopenia. Among the parvovirus B19 positive children, duration of disease was brief in three children treated with immunoglobulin butchronic in the remaining three patients given high-dose steroids. Prospective studies are needed to confirm these initial observations, This virus should be considered as a possible aetiologic agent in some children with ITP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:45:45