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Titolo:
The carbohydrate moiety of human glycophorin in CDG syndrome
Autore:
Krotkiewska, B; Zwierz, K; Krotkiewski, H;
Indirizzi:
Univ Wroclaw, Sch Med, Dept Biochem, PL-50138 Wroclaw, Poland Univ Wroclaw Wroclaw Poland PL-50138 t Biochem, PL-50138 Wroclaw, Poland Univ Med Sch, Dept Pharmaceut Biochem, Bialystok, Poland Univ Med Sch Bialystok Poland ept Pharmaceut Biochem, Bialystok, Poland Polish Acad Sci, Ludwik Hirszfeld Inst Immunol & Expt Therapy, Dept Immunochem, Wroclaw, Poland Polish Acad Sci Wroclaw Poland herapy, Dept Immunochem, Wroclaw, Poland
Titolo Testata:
ACTA BIOCHIMICA POLONICA
fascicolo: 2, volume: 46, anno: 1999,
pagine: 371 - 376
SICI:
0001-527X(1999)46:2<371:TCMOHG>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIENT GLYCOPROTEIN-SYNDROME; LECTINS; TRANSFERRIN; SERUM; ACID;
Keywords:
human glycophorin; CDG syndrome; lectins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Krotkiewski, H R Weigla 12, PL-53114 Wroclaw, Poland R Weigla 12 WroclawPoland PL-53114 53114 Wroclaw, Poland
Citazione:
B. Krotkiewska et al., "The carbohydrate moiety of human glycophorin in CDG syndrome", ACT BIOCH P, 46(2), 1999, pp. 371-376

Abstract

Human glycophorin, the major sialoglycoprotein of erythrocyte membranes, was isolated from erythrocytes of healthy individuals and four patients withCDG syndrome. Sugar analysis revealed lower carbohydrate content in three out of four CDG-glycophorin samples. In order to characterize closer the glycosylation differences between glycophorin samples in health and disease, reaction with four biotinylated lectins was performed, using ELISA procedure on polystyrene microplates. Results obtained so far strongly suggest thatboth N- and O-glycans of glycophorin are affected in CDG syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 12:02:33