Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Iscom and iscom-matrix enhance by intranasal route the IgA responses to OVA and rCTB in local and remote mucosal secretions
Autore:
Ekstrom, J; Hu, KF; Bengtsson, KL; Morein, B;
Indirizzi:
Swedish Univ Agr Sci, Fac Vet Med, Dept Vet Microbiol, Biomed Ctr,Sect Virol, Uppsala, Sweden Swedish Univ Agr Sci Uppsala Sweden med Ctr,Sect Virol, Uppsala, Sweden Natl Vet Inst, Dept Virol, Biomed Ctr, S-75123 Uppsala, Sweden Natl Vet Inst Uppsala Sweden S-75123 Biomed Ctr, S-75123 Uppsala, Sweden
Titolo Testata:
VACCINE
fascicolo: 20-21, volume: 17, anno: 1999,
pagine: 2690 - 2701
SICI:
0264-410X(19990604)17:20-21<2690:IAIEBI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOXIN-B-SUBUNIT; SYSTEMIC ANTIBODY-RESPONSES; RESPIRATORY SYNCYTIAL VIRUS; HEAT-LABILE TOXIN; CHOLERA-TOXIN; IMMUNE-RESPONSES; ADJUVANT ACTIVITY; ESCHERICHIA-COLI; IMMUNOSTIMULATING COMPLEXES; DELIVERY SYSTEM;
Keywords:
iscoms; mucosal immunity; rCTB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Morein, B Swedish Univ Agr Sci, Fac Vet Med, Dept Vet Microbiol, Biomed Ctr,Sect Virol, Uppsala, Sweden Swedish Univ Agr Sci Uppsala Sweden ct Virol, Uppsala, Sweden
Citazione:
J. Ekstrom et al., "Iscom and iscom-matrix enhance by intranasal route the IgA responses to OVA and rCTB in local and remote mucosal secretions", VACCINE, 17(20-21), 1999, pp. 2690-2701

Abstract

Iscoms, with rCTB incorporated via the GM1 receptor, enhanced in mice the mucosal immunogenicity of rCTB as antigen after intranasal (i.n.) administration both by inducing IgA response in the remote intestinal tract mucosa and by a 100-fold increase of the specific IgA locally in the lungs. Iscom-matrix as a separate entity mixed with rCTB enhanced the rCTB-IgA response similarly. While OVA in iscoms induced high mucosal IgA responses, iscom-matrix co-administered with OVA induced low or no mucosal IEA response to OVA. A synergism between iscoms and rCTB could only be seen as an adjuvant targeting effect enhancing the IgA response to OVA in the remote genital tract mucosa. In serum, the immunomodulatory effect of iscoms after i.n. administration was seen as an enhanced serum IgG2a response. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:12:03