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Titolo:
Alterations of transforming growth factor beta 1 (TGF-beta 1) and TGF betareceptor expressions with progression in Dunning rat prostatic adenocarcinoma sublines
Autore:
Wikstrom, P; Lindh, G; Bergh, A; Damber, JE;
Indirizzi:
Umea Univ, Dept Urol & Androl, S-90185 Umea, Sweden Umea Univ Umea Sweden S-90185 , Dept Urol & Androl, S-90185 Umea, Sweden Umea Univ, Dept Pathol, S-90185 Umea, Sweden Umea Univ Umea Sweden S-90185 ea Univ, Dept Pathol, S-90185 Umea, Sweden
Titolo Testata:
UROLOGICAL RESEARCH
fascicolo: 3, volume: 27, anno: 1999,
pagine: 185 - 193
SICI:
0300-5623(199906)27:3<185:AOTGFB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER CELL-LINES; II RECEPTOR; VENTRAL PROSTATE; ESTROGEN-TREATMENT; IN-VITRO; TUMOR; GROWTH-FACTOR-BETA-1; PROLIFERATION; ANGIOGENESIS; CASTRATION;
Keywords:
prostatic adenocarcinoma; TGF-beta 1; TGF beta receptors; mRNA; protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Damber, JE Umea Univ, Dept Urol & Androl, S-90185 Umea, Sweden Umea Univ Umea Sweden S-90185 & Androl, S-90185 Umea, Sweden
Citazione:
P. Wikstrom et al., "Alterations of transforming growth factor beta 1 (TGF-beta 1) and TGF betareceptor expressions with progression in Dunning rat prostatic adenocarcinoma sublines", UROL RES, 27(3), 1999, pp. 185-193

Abstract

Transforming growth factor-beta 1 (TGF-beta 1) inhibits epithelial cell proliferation in the normal prostate. Prostate tumours express high levels ofTGF-beta 1, and seem to acquire resistance to its anti-proliferative effects with tumour progression. In this study, TGF beta variations with tumour progression were examined in the Dunning prostatic adenocarcinoma model. Expression of TGF-beta 1 and TGF beta receptor type I and type II (TGF beta-RI and TGF beta-RII) in rat dorsolateral prostate (DLP) and Dunning tumour sublines (PAP, AT-1, AT-2, AT-3 and MatLyLu) was examined in vitro and in vivo, using competitive reverse transcription-polymerase chain reaction (RT-PCR), Northern and Western blot, and immunohistochemistry. All tumours expressed elevated levels of TGF-beta 1 and TGF beta-RI mRNA, when compared withthe DLP (P less than or equal to 0.05). All rumours except MatLyLu also expressed elevated levels of TGF beta-RII mRNA (P less than or equal to 0.05). Interestingly, TGF beta-RII protein levels were very low in the highly metastatic AT-3 and MatLyLu rumours in vivo, when compared with levels in thePAP, AT-1, and AT-2 rumours. This difference was not detected for the AT-1, AT-2, and AT-3 cells in vitro. Immunostaining of TGF-beta 1, TGF beta-RI,and TGF beta-RII was localised principally in normal and tumour epithelialcells, and occasionally in smooth muscle cells. In conclusion, high expression of TGF-beta 1 and TGF beta-RI and low expression of TGF beta-RII may contribute to tumour progression and metastasis in the Dunning prostatic adenocarcinoma model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:39:19