Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Human herpes virus-8 and other risk factors for Kaposi's sarcoma in kidneytransplant recipients
Autore:
Farge, D; Lebbe, C; Marjanovic, Z; Tuppin, P; Mouquet, C; Peraldi, HN; Lang, P; Hiesse, C; Antoine, C; Legendre, C; Bedrossian, J; Gagnadoux, HF; Loirat, C; Pellet, C; Sheldon, J; Golmard, JL; Agbalika, F; Schulz, TF;
Indirizzi:
Hop St Louis, Serv Med Interne, F-75010 Paris, France Hop St Louis ParisFrance F-75010 erv Med Interne, F-75010 Paris, France Etab Francais Greffes, F-75012 Paris, France Etab Francais Greffes ParisFrance F-75012 reffes, F-75012 Paris, France Dept Med Microbiol & Genitourinary Med, Mol Virol Grp, Liverpool, Merseyside, England Dept Med Microbiol & Genitourinary Med Liverpool Merseyside England land
Titolo Testata:
TRANSPLANTATION
fascicolo: 9, volume: 67, anno: 1999,
pagine: 1236 - 1242
SICI:
0041-1337(19990515)67:9<1236:HHVAOR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN HERPESVIRUS-8; DNA-SEQUENCES; SAUDI-ARABIA; HUMAN-HERPESVIRUS-8; TRANSMISSION; INFECTION; THERAPY; IMMUNOSUPPRESSION; ANTIBODIES; POPULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Farge, D Hop St Louis, Serv Med Interne, 1 Ave Claude Vellefaux, F-75010 Paris, France Hop St Louis 1 Ave Claude Vellefaux Paris France F-75010 France
Citazione:
D. Farge et al., "Human herpes virus-8 and other risk factors for Kaposi's sarcoma in kidneytransplant recipients", TRANSPLANT, 67(9), 1999, pp. 1236-1242

Abstract

Background. The exact reasons for the high incidence of Kaposi's sarcoma (KS) after kidney transplantation are still unknown. Immunosuppression is classically considered as the main risk factor, but the relative risk contributed by the patient's geographic origin and by human herpes virus (HHV)-8 infection still has to be determined. Methods. We carried out a retrospective and a prospective study among kidney transplant recipients (TP) to identify the risk factors for posttransplantation KS. Each of 30 KS patients was matched with two controls to investigate the association with geographic origin, immunosuppressive regimen, HHV-8 antibodies before and after transplantation, and other infections. AmongTP with new onset of KS, we prospectively evaluated HHV-8 serology and viremia in response to decreased immunosuppression. Results. African and Middle East origins, past infection with hepatitis B,hemoglobin level <12 g/dl, lymphocyte count <750/mm(3) at the time of diagnosis and initial use of polyclonal antilymphocyte sera were risk factors for KS, After multivariate analysis, origin in Africa or Middle East and useof antilymphocyte sera for induction remained as independent risk factors. Sixty-eight percent (17/25) of TP with HHV-8 antibodies before or after transplantation developed KS compared with 3% (1/33) of seronegative TP (P<0.00001). HHV-8 DNA was detectable in seven of nine peripheral blood mononuclear cells (PBMC) and in six of six KS lesions at diagnosis; it became negative in PBMC in three of five patients in parallel with tumor regression. Conclusion. African and Middle East geographic origins, HHV-8 infection before and after kidney transplantation, and initial use of polyclonal antilymphocyte sera were independent risk factors for KS. The presence of HHV-8 antibodies before or after transplantation was highly predictive of the emergence of posttransplantation KS and conferred a 28-fold increased risk of KS (odds ratio=28.4; 95% confidence interval: 4.9-279), Detection of HHV-8 DNA within PBMC and KS lesions seems related to tumor burden and evolution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:29:35