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Titolo:
IBOTENATE LESION OF THE MEDIAL HYPOTHALAMUS ALTERS THE SALT INTAKE AND PRESSOR-RESPONSES TO ACTIVATION OF THE MEDIAN PREOPTIC NUCLEUS IN RATS
Autore:
DOVALE CF; CAMARGO GMPA; RENZI A; LUIZ AC; SAAD WA; HETEM S; CAMARGO LAA;
Indirizzi:
PAULISTA STATE UNIV,UNESP,SCH DENT,DEPT PHYSIOL,1680 HUMAITA ST BR-14801903 ARARAQUARA SP BRAZIL PAULISTA STATE UNIV,UNESP,SCH DENT,DEPT PHYSIOL BR-14801903 ARARAQUARA SP BRAZIL
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 1, volume: 91, anno: 1997,
pagine: 31 - 37
SICI:
0928-4257(1997)91:1<31:ILOTMH>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTALLY-INDUCED DRINKING; VENTRAL LAMINA TERMINALIS; ANGIOTENSIN-II; LATERAL HYPOTHALAMUS; SUBFORNICAL ORGAN; ADRENERGIC PATHWAYS; RENAL EXCRETION; INDUCED THIRST; WATER-INTAKE; AREA;
Keywords:
ADRENERGIC AGONISTS; MEDIAL HYPOTHALAMUS; ANGIOTENSIN II; ARTERIAL PRESSURE; SALT INTAKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
C.F. Dovale et al., "IBOTENATE LESION OF THE MEDIAL HYPOTHALAMUS ALTERS THE SALT INTAKE AND PRESSOR-RESPONSES TO ACTIVATION OF THE MEDIAN PREOPTIC NUCLEUS IN RATS", J PHYSL-PAR, 91(1), 1997, pp. 31-37

Abstract

We investigated the influence of ibotenic acid lesions of the medial hypothalamus (MH) on salt appetite and arterial blood pressure responses induced by angiotensinergic and adrenergic stimulation of the median preoptic nucleus (MnPO) of rats. Previous injection of the adrenergic agonists norepinephrine, clonidine, phenylephrine, and isoproterenolinto the MnPO of sham MH-lesioned rats caused no change in the sodiumintake induced by ANG II. ANG II injected into the MnPO of MH-lesioned rats increased sodium intake compared with sham-lesioned rats. Previous injection of clonidine and isoproterenol increased, whereas phenylephrine abolished the salt intake induced by ANG II into the MnPO of MH-lesioned rats. Previous injection of norepinephrine and clonidine into the MnPO of sham MH-lesioned rats caused no change in the mean arterial pressure (MAP) induced by ANG II. Under the same conditions, previous injection of phenylephrine increased, whereas isoproterenol reversed the increase in MAP induced by angiotensin II (ANG II). ANG II injected into the MnPO of MH-lesioned rats induce a decrease in MAP compared with sham-lesioned rats. Previous injection of phenylephrine or norepinephrine into the MnPO of MH-lesioned rats induced a negative MAP,whereas pretreatment with clonidine or isoproterenol increased the MAP produced by ANG II injected into the MnPO of sham- or MH-lesioned rats. These data show that ibotenic acid lesion of the MH increases the sodium intake and presser responses induced by the concomitant angiotensinergic, alpha(2) and beta adrenergic activation of the MnPO, whereas alpha(1) activation may have opposite effects. MH involvement in excitatory and inhibitory mechanisms related to sodium intake and MAP control is suggested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 00:40:50