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Titolo:
RELAXIVITY STUDY AND X-RAY STRUCTURE OF TRIAMINE-N,N',N''-TRIACETIC-N,N''-BIS(BENZYLAMIDE) - A POTENTIAL MRI CONTRAST AGENT
Autore:
WANG YM; CHENG TH; SHEU RS; CHEN IT; CHIANG MY;
Indirizzi:
KAOHSIUNG MED COLL,SCH CHEM KAOHSIUNG 807 TAIWAN KAOHSIUNG MED COLL,DEPT RADIOL KAOHSIUNG 807 TAIWAN NATL SUN YAT SEN UNIV,DEPT CHEM KAOHSIUNG 80424 TAIWAN
Titolo Testata:
Journal of the Chinese Chemical Society
fascicolo: 2, volume: 44, anno: 1997,
pagine: 123 - 128
SICI:
0009-4536(1997)44:2<123:RSAXSO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
GADODIAMIDE; COMPLEXES; DESIGN;
Keywords:
CRYSTAL STRUCTURE; GADOLINIUM COMPLEX; RELAXIVITY; MRI CONTRAST AGENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
Y.M. Wang et al., "RELAXIVITY STUDY AND X-RAY STRUCTURE OF TRIAMINE-N,N',N''-TRIACETIC-N,N''-BIS(BENZYLAMIDE) - A POTENTIAL MRI CONTRAST AGENT", Journal of the Chinese Chemical Society, 44(2), 1997, pp. 123-128

Abstract

The new bis(amide) derivatives of DTPA (diethylenetriamine-N,N,N',N '',N ''-pentaacetic acid), diethylenetriamine-N,N',N ''-triacetic-N,N ''-bis(benzylamide) (DTPA-BBA) have been synthesized. The crystal structure of gadolinium(III) complex of DTPA-BBA ([Gd(DTPA-BBA)]) has been determined by X-ray crystallography: C28H52GdN5O17, M-w = 889 g mol(-1), space group P (1) over bar (#2) (triclinic), a = 12.645(4), b = 14.125(8), c = 12.623(4) Angstrom, alpha = 111.60(3), beta = 114.79(3), gamma = 88.39(4)degrees, V = 1881(1) Angstrom(3), Z = 2, D-x = 1.569 g/cm(3), lambda(Mo K alpha) = 0.71069 Angstrom, mu = 18.44 cm(-1), finalR = 0.047, R-w = 0.046 for 3755 independent observed reflections at 23 degrees C. The coordination sphere of Gd(III) comprises three amine nitrogens, two amide oxygens, three carboxylic acid oxygens, and one water. The relaxivitiy of Gd(III) complex was determined to be R1 = 4.08(4) and R2 = 6.06(5) dm(3) mmol(-1) s(-1) at pH = 7.0, 20 MHz, and 37(1)degrees C. Additionally, the R1 relaxivity for Gd(III) chelate was found to be invariant with respect to pH changes over the range of 2-10. This indicates that a constant inner-sphere hydration number is associated with the [Gd(DTPA-BBA)] complex. Hence the high stability of the complex is demonstrated.

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Documento generato il 26/09/20 alle ore 00:27:48