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Titolo:
The role of placental Fas ligand in maintaining immune privilege at maternal-fetal interfaces
Autore:
Guller, S; LaChapelle, L;
Indirizzi:
NYU, Sch Med, Dept Obstet & Gynecol, New York, NY 10016 USA NYU New York NY USA 10016 , Dept Obstet & Gynecol, New York, NY 10016 USA
Titolo Testata:
SEMINARS IN REPRODUCTIVE ENDOCRINOLOGY
fascicolo: 1, volume: 17, anno: 1999,
pagine: 39 - 44
SICI:
0734-8630(1999)17:1<39:TROPFL>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; NATURAL-KILLER-CELLS; METRIAL GLAND-CELLS; GROWTH-FACTOR-BETA; CHORIOCARCINOMA CELLS; ALLOGRAFT SURVIVAL; INDUCED APOPTOSIS; HUMAN TROPHOBLAST; DEATH FACTOR; NK CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Guller, S NYU, Sch Med, Dept Obstet & Gynecol, 550 1st Ave, New York, NY 10016 USA NYU 550 1st Ave New York NY USA 10016 ve, New York, NY 10016 USA
Citazione:
S. Guller e L. LaChapelle, "The role of placental Fas ligand in maintaining immune privilege at maternal-fetal interfaces", SEM REP END, 17(1), 1999, pp. 39-44

Abstract

It is now recognized that immunosuppressive factors synthesized by placenta may play a critical role in the maintenance of pregnancy. Over the last several years our group and others have formulated a hypothesis that trophoblast Fas ligand (FasL) plays an important role in maintaining fetal immune privilege in human pregnancy by actively promoting apoptosis (programmed cell death) of activated maternal lymphocytes bearing Fas (i.e., the Fast receptor). This review initially provides background information and updates aspects of the Fas/FasL signaling system, including the role of caspases andmolecules recruited to the Fasl/Fas signaling complex and the revised functions ascribed to membrane and soluble forms of FasL. Information is then presented concerning the role of FasL at immune-privileged sites including the eye and testis. Pathways through which the placenta and tumors avoid mayavoid immune clearance vis-a-vis the FasL/Fas signaling cascade are described. A model is then presented through which Fast production by human syncytiotrophoblasts and extravillous trophoblasts may protect the fetus againstthe cytolytic actions of activated Fas-bearing maternal lymphocytes in theintervillous space and in the placental bed, respectively We conclude witha review of studies in support this model that specifically demonstrate trophoblast expression of FasL and identify potential lymphocyte targets (i.e., Fas-expressing maternal immune cells) of trophoblast Fast.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:58:46