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Titolo:
Hepatic cytochrome oxidase in rats with microsurgical cholestasis or portocaval shunt
Autore:
Lopez, L; Begega, A; Arias, JL; Lorente, L; Aller, MA; Poveda, MD; Arias, J;
Indirizzi:
Univ Oviedo, Sch Psychol, Psychobiol Lab, Oviedo, Spain Univ Oviedo Oviedo Spain do, Sch Psychol, Psychobiol Lab, Oviedo, Spain
Titolo Testata:
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
fascicolo: 5, volume: 91, anno: 1999,
pagine: 370 - 373
SICI:
1130-0108(199905)91:5<370:HCOIRW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SECONDARY BILIARY-CIRRHOSIS; ELECTRON-TRANSPORT CHAIN; LIVER-MITOCHONDRIA; PORTAL BLOOD; MODEL; REEVALUATION; HEPATOCYTE; PORTACAVAL; DISEASE; CELLS;
Keywords:
cytochrome oxidase; cholestasis; portocaval shunt; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Aller, MA Univ Complutense Madrid, Fac Med, Catedra Cirurgia, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 040 Madrid, Spain
Citazione:
L. Lopez et al., "Hepatic cytochrome oxidase in rats with microsurgical cholestasis or portocaval shunt", REV ESP E D, 91(5), 1999, pp. 370-373

Abstract

AIMS: portocaval shunt and extrahepatic cholestasis are experimental models of chronic hepatic insufficiency of different etiology and histological characteristics, and which probably also differ in the mechanism of impairment of oxidative metabolism. To test this hypothesis we measured hepatic cytochrome oxidase. METHODS: cytochrome oxidase was assayed with a histochemical technique in three groups of Wistar rats: A (n = 8) control; B (n = 8) microsurgical extrahepatic cholestasis; and C (n = 8) end-to-side portocaval shunt. RESULTS: cytochrome oxidase activity was lowest in group B, both in the left middle (p = 0.00019) and in the inferior caudate (p = 0.00014) hepatic lobes, and was highest in group C in both hepatic lobes, especially in the left middle lobe (p = 0.0029). CONCLUSION: the decrease in cytochrome oxidase activity in the liver of rats with extrahepatic cholestasis and the increase in animals subjected to portal flow deprivation demonstrate the different nature of the impairment in hepatic oxidative metabolism in these two pathological conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:43:35