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Titolo:
Lipid-based amphotericin B formulations: from animals to man
Autore:
Bekersky, I; Fielding, RM; Buell, D; Lawrence, I;
Indirizzi:
Fujisawa Healthcare Inc, Deerfield, IL 60015 USA Fujisawa Healthcare Inc Deerfield IL USA 60015 c, Deerfield, IL 60015 USA Biologist Serv, Boulder, CO 80302 USA Biologist Serv Boulder CO USA 80302Biologist Serv, Boulder, CO 80302 USA
Titolo Testata:
PHARMACEUTICAL SCIENCE & TECHNOLOGY TODAY
fascicolo: 6, volume: 2, anno: 1999,
pagine: 230 - 236
SICI:
1461-5347(199906)2:6<230:LABFFA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVASIVE FUNGAL-INFECTIONS; COLLOIDAL DISPERSION; NEUTROPENIC PATIENTS; LIPOSOMAL FORMULATION; AMBISOME; EFFICACY; PHARMACOKINETICS; TOXICITY; THERAPY; CANCER;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Bekersky, I Fujisawa Healthcare Inc, 3 Pkwy N, Deerfield, IL 60015 USA Fujisawa Healthcare Inc 3 Pkwy N Deerfield IL USA 60015 15 USA
Citazione:
I. Bekersky et al., "Lipid-based amphotericin B formulations: from animals to man", PHARM SCI T, 2(6), 1999, pp. 230-236

Abstract

Amphotericin B has been the mainstay of systemic antifungal therapy for over 30 years, despite its serious side-effects, and, although numerous alternative antifungal agents have been developed, none to date has matched the efficacy of amphotericin B. However, modern drug delivery technology has improved the safety of amphotericin B by incorporating it into lipid-based delivery systems, including liposomes. Three such formulations, based on the natural affinity of amphotericin B for lipids, are currently marketed. All increase the therapeutic index of amphotericin B, thereby allowing more aggressive treatment than is possible with the conventional product. However, they differ in structure, side-effect profiles and evidence of proven efficacy as discussed in this review.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:30:00