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Titolo:
Markers of inflammation and bronchial reactivity in children with asthma, exposed to animal dander in school dust
Autore:
Lonnkvist, K; Hallden, G; Dahlen, SE; Enander, I; van Hage-Hamsten, M; Kumlin, M; Hedlin, G;
Indirizzi:
Huddinge Univ Hosp, Dept Paediat, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 iat, S-14186 Huddinge, Sweden Karolinska Hosp, Dept Lab Med, Div Clin Immunol, S-10401 Stockholm, SwedenKarolinska Hosp Stockholm Sweden S-10401 unol, S-10401 Stockholm, Sweden Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10401 Med, S-10401 Stockholm, Sweden Pharmacia Upjohn Diagnost AB, Uppsala, Sweden Pharmacia Upjohn Diagnost AB Uppsala Sweden iagnost AB, Uppsala, Sweden
Titolo Testata:
PEDIATRIC ALLERGY AND IMMUNOLOGY
fascicolo: 1, volume: 10, anno: 1999,
pagine: 45 - 52
SICI:
0905-6157(199902)10:1<45:MOIABR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
EOSINOPHIL PEROXIDASE; INDUCED SPUTUM; CHALLENGE; ALLERGEN; RESPONSIVENESS; LAVAGE; METHACHOLINE; PURIFICATION; INHALATION; HISTAMINE;
Keywords:
asthma; schoolchildren; eosinophils; eosinophil cationic protein; methacholine challenge; animal dander allergy; sputum; NAL; allergen exposure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Lonnkvist, K Huddinge Univ Hosp, Dept Paediat, S-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden S-14186 Huddinge, Sweden
Citazione:
K. Lonnkvist et al., "Markers of inflammation and bronchial reactivity in children with asthma, exposed to animal dander in school dust", PEDIAT A IM, 10(1), 1999, pp. 45-52

Abstract

Several studies have confirmed the presence of animal dander allergens in school dust but the effect of this indirect animal exposure on health has not been evaluated. In this study we investigated bronchial reactivity and markers of eosinophil activity and inflammation during two separate weeks ofschool in 10 children with mild asthma and a positive skin prick test to cat and dog. At the beginning and the end of the first week the children underwent bronchial challenges with methacholine, and at the beginning and theend of the second week they underwent nasal lavages (NAL) and induced sputum samplings. Blood and urine samples for analysis of inflammatory markers were obtained before and after both school weeks. Peak expiratory flow (PEF) and symptoms of asthma and allergy were recorded daily, and spirometry was performed on each visit. The exposure to animal dander allergens was estimated from dust samples obtained in the subjects' schools and homes. Bronchial sensitivity to methacholine increased in the week when this was measured. The proportion of eosinophils in peripheral blood, and urinary eosinophil protein X (EPX), decreased in both weeks. There was a trend towards an increase of eosinophil peroxidase (EPO) and myeloperoxidase (MPO) in sputum in the week when these proteins were measured. The concentrations of cat (Fel dl) and dog (Can fl) allergens were higher in dust collected in schools than in homes. Our results show that in children with mild asthma and animaldander allergy, there is a significantly increased bronchial sensitivity to methacholine after one school week. There is also a significant decrease in the number of circulating eosinophils and a trend towards an increase ofsputum EPO, which could correlate with the early phase of eosinophil recruitment to the lungs. These effects may be related to the continuous exposure to animal allergens in school dust.

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Documento generato il 29/10/20 alle ore 21:07:16