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Titolo:
Hypocholesterolemic effect of hesperetin mediated by inhibition of 3-hydroxy-3-methylgultaryl coenzyme a reductase and acyl coenzyme A: Cholesterol acyltransferase in rats fed high-cholesterol diet
Autore:
Lee, SH; Jeong, TS; Park, YB; Kwon, YK; Choi, MS; Bok, SH;
Indirizzi:
Korea Res Inst Biosci & Biotechnol, KIST, Taejon 305600, South Korea KoreaRes Inst Biosci & Biotechnol Taejon South Korea 305600 South Korea Kyungpook Natl Univ, Dept Food Sci & Nutr, Taegu 702701, South Korea Kyungpook Natl Univ Taegu South Korea 702701 , Taegu 702701, South Korea Kyungpook Natl Univ, Dept Genet Engn, Taegu 702701, South Korea Kyungpook Natl Univ Taegu South Korea 702701 , Taegu 702701, South Korea
Titolo Testata:
NUTRITION RESEARCH
fascicolo: 8, volume: 19, anno: 1999,
pagine: 1245 - 1258
SICI:
0271-5317(199908)19:8<1245:HEOHMB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN RECEPTOR; CORONARY HEART-DISEASE; SERUM-CHOLESTEROL; A REDUCTASE; LOWERING AGENT; ACAT INHIBITOR; ABSORPTION; LIVER; COA; ESTERIFICATION;
Keywords:
high-cholesterol diet; hesperetin; HMG-CoA reductase; ACAT; fecal neutral sterols;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Jeong, TS Korea Res Inst Biosci & Biotechnol, KIST, POB 115, Taejon 305600, South Korea Korea Res Inst Biosci & Biotechnol POB 115 Taejon South Korea 305600
Citazione:
S.H. Lee et al., "Hypocholesterolemic effect of hesperetin mediated by inhibition of 3-hydroxy-3-methylgultaryl coenzyme a reductase and acyl coenzyme A: Cholesterol acyltransferase in rats fed high-cholesterol diet", NUTR RES, 19(8), 1999, pp. 1245-1258

Abstract

HMG-CoA reductase and ACAT are associated with regulation of cholesterol metabolism. In present study, the deglycosylated form of hesperidin, hesperetin, was tested both in vivo and in vitro to examine potential differences in mechanism through which hesperetin might affect cholesterol metabolism. When tested ill vitro, hesperetin had no inhibitory effect on either HMG-CoA reductase or ACAT. Male rats were fed a high-cholesterol (1%, w/w) diet with or without hesperetin for 42 d to determine hesperetin effects on plasma lipid levels and hepatic cholesterol metabolism. Hesperetin did not change the levels of hepatic lipids, but decreased the concentration of plasma cholesterol (3.24 mmol/L vs. 3.80 mmol/L). Plasma triglyceride level was notdifferent between control and hesperetin-supplemented group (1.12 mol/L vs. 1.29 mmol/L). HMG-CoA reductase and ACAT activities in the liver were significantly reduced by hesperetin supplementation (2005.0 pmole.min(-1) mg proteim(-1) vs. 2487.2 pmole.min(-1) mg protein`' for HMG-CoA reductase, 616.4 pmole.min(-1) mg proteim(-1) vs. 806.2 pmoles/min per mg for ACAT). The most noticeble change by the hesperetin supplementation was a marked decrease in daily excretion of fecal neutral sterols (178.7 mg/d vs. 521.9 mg/d). Results indicate that hesperetin decreased the plasma cholesterol level inrats fed a high-cholesterol diet. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:31:02