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Titolo:
Characterization of voltage dependent calcium channels on the lateral olivocochlear efferent fibers of the guinea pig
Autore:
Gaborjan, A; Vizi, ES;
Indirizzi:
Hungarian Acad Sci, Inst Expt Med, H-1450 Budapest, Hungary Hungarian AcadSci Budapest Hungary H-1450 Med, H-1450 Budapest, Hungary
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 269, anno: 1999,
pagine: 49 - 51
SICI:
0304-3940(19990702)269:1<49:COVDCC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINOGLYCOSIDE ANTIBIOTICS; OMEGA-CONOTOXIN; COCHLEA; MODULATION; AGONIST; BINDING; NEURONS; CELLS; RAT;
Keywords:
voltage-dependent calcium channels; lateral olivocochlear efferents; in vitro superfusion; dopamine release;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Vizi, ES Hungarian Acad Sci, Inst Expt Med, POB 67, H-1450 Budapest, Hungary Hungarian Acad Sci POB 67 Budapest Hungary H-1450 apest, Hungary
Citazione:
A. Gaborjan e E.S. Vizi, "Characterization of voltage dependent calcium channels on the lateral olivocochlear efferent fibers of the guinea pig", NEUROSCI L, 269(1), 1999, pp. 49-51

Abstract

Using in vitro superfusion technique the release of [H-3]-dopamine from the lateral olivocochlear efferent fibers of the cochlea was investigated. Our previous study gave the first neurochemical evidence for the transmitter role of dopamine and proved its neuronal origin. Using specific antagonistsnow we characterized the voltage-dependent calcium channels (VDCCs) involved in the release of dopamine evoked by electrical stimulation of the cochlear tissue. Verapamil or nifedipine, and Ni2+ failed to affect the release,indicating that neither L-, nor T-type VDCCs are essential for the releaseprocess. The fact that omega-conotoxin inhibited the release of dopamine from lateral olivocochlear efferent fibers suggests, that N-type VDCCs are required for the calcium influx during electrical stimulation. These VDCCs could be presynaptic targets of modulation of the dopamine release under pathological conditions or in therapy. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 11:40:35