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Titolo:
RET-RGS, a retina-specific regulator of G-protein signaling, is located insynaptic regions of the rat retina
Autore:
Faurobert, E; Scotti, A; Hurley, JB; Chabre, M;
Indirizzi:
CNRS, Inst Pharmacol Mol & Cellulaire, UPR 411, F-06560 Valbonne, France CNRS Valbonne France F-06560 llulaire, UPR 411, F-06560 Valbonne, France Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ghes Med Inst, Seattle, WA 98195 USA
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 269, anno: 1999,
pagine: 41 - 44
SICI:
0304-3940(19990702)269:1<41:RARROG>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
GTPASE-ACTIVATING PROTEIN; IN-VITRO; TRANSDUCIN; PHOSPHORYLATION; LOCALIZATION; BRAIN; GAIP;
Keywords:
regulator of G protein signaling; G protein; immunolocalization; retina;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Faurobert, E CNRS, Inst Pharmacol Mol & Cellulaire, UPR 411, 660 Route Lucioles, F-06560 Valbonne, France CNRS 660 Route Lucioles Valbonne France F-06560 onne, France
Citazione:
E. Faurobert et al., "RET-RGS, a retina-specific regulator of G-protein signaling, is located insynaptic regions of the rat retina", NEUROSCI L, 269(1), 1999, pp. 41-44

Abstract

RGS (regulators of G protein signaling) proteins negatively regulate the cu subunit of G proteins by accelerating their intrinsic GTPase activity. Ina previous work, we reported the cloning of a cDNA encoding for a new RGS protein, RET-RGS. We showed that it is specifically expressed in the retina, notably by photoreceptor cells and that it has an in vitro GAP activity on transducin. To understand the role of RET-RGS, and in particular to determine whether it regulates the phototransduction cascade in photoreceptor cells, RET-RGS was immunolocalized on rat retina sections. Whereas no labeling was detected in outer nor inner segments of photoreceptors cells, dense immunoreactive products were localized in the outer and inner plexiform layers which correspond to the regions of synaptic interplay between the different neurons of the retina including the photoreceptor cells. These results rule out a role of RET-RGS on the phototransduction cascade and suggest that it may participate in retina specific synaptic transductions. (C) 1999 Elsevier Science ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/21 alle ore 05:53:30